| Nomenclature |
HGNC (Hugo) | OBSCN 15719 |
LRG (Locus Reference Genomic) | LRG_412 |
| Cards |
Entrez_Gene (NCBI) | OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF |
Aliases | ARHGEF30; UNC89 |
GeneCards (Weizmann) | OBSCN |
Ensembl hg19 (Hinxton) | ENSG00000154358 [Gene_View] |
Ensembl hg38 (Hinxton) | ENSG00000154358 [Gene_View]  ENSG00000154358 [Sequence] chr1:228208044-228361250 [Contig_View] OBSCN [Vega] |
ICGC DataPortal | ENSG00000154358 |
TCGA cBioPortal | OBSCN |
AceView (NCBI) | OBSCN |
Genatlas (Paris) | OBSCN |
SOURCE (Princeton) | OBSCN |
Genetics Home Reference (NIH) | OBSCN |
| Genomic and cartography |
GoldenPath hg38 (UCSC) | OBSCN - chr1:228208044-228361250 + 1q42.13 [Description] (hg38-Dec_2013) |
GoldenPath hg19 (UCSC) | OBSCN - 1q42.13 [Description] (hg19-Feb_2009) |
GoldenPath | OBSCN - 1q42.13 [CytoView hg19] OBSCN - 1q42.13 [CytoView hg38] |
ImmunoBase | ENSG00000154358 |
genome Data Viewer NCBI | OBSCN [Mapview hg19] |
OMIM | 608616 |
| Gene and transcription |
Genbank (Entrez) | AB046776 AB046859 AJ002535 AK024186 AK097489 |
RefSeq transcript (Entrez) | NM_001098623 NM_001271223 NM_052843 |
RefSeq genomic (Entrez) | |
Consensus coding sequences : CCDS (NCBI) | OBSCN |
Alternative Splicing Gallery | ENSG00000154358 |
Gene Expression | OBSCN [ NCBI-GEO ] OBSCN [ EBI - ARRAY_EXPRESS ]
OBSCN [ SEEK ] OBSCN [ MEM ] |
Gene Expression Viewer (FireBrowse) | OBSCN [ Firebrowse - Broad ] |
Genevisible | Expression of OBSCN in : [tissues]  [cell-lines]  [cancer]  [perturbations]   |
BioGPS (Tissue expression) | 84033 |
GTEX Portal (Tissue expression) | OBSCN |
Human Protein Atlas | ENSG00000154358-OBSCN [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
UniProt/SwissProt | Q5VST9 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
NextProt | Q5VST9 [Sequence] [Exons] [Medical] [Publications] |
With graphics : InterPro | Q5VST9 |
Splice isoforms : SwissVar | Q5VST9 |
PhosPhoSitePlus | Q5VST9 |
Domaine pattern : Prosite (Expaxy) | DH_2 (PS50010) FN3 (PS50853) IG_LIKE (PS50835) IQ (PS50096) PH_DOMAIN (PS50003) PROTEIN_KINASE_ATP (PS00107) PROTEIN_KINASE_DOM (PS50011) PROTEIN_KINASE_ST (PS00108) PROTEIN_KINASE_TYR (PS00109) SH3 (PS50002) |
Domains : Interpro (EBI) | DBL_dom_sf DH-domain FN3_dom FN3_sf Ig-like_dom Ig-like_dom_sf Ig-like_fold Ig_I-set Ig_sub Ig_sub2 Ig_V-set IQ_motif_EF-hand-BS Kinase-like_dom_sf Obscurin_SH3 PH-like_dom_sf PH_domain Prot_kinase_dom Protein_kinase_ATP_BS Ser/Thr_kinase_AS SH3-like_dom_sf SH3_domain Tyr_kinase_AS |
Domain families : Pfam (Sanger) | fn3 (PF00041) I-set (PF07679) IQ (PF00612) Pkinase (PF00069) RhoGEF (PF00621) |
Domain families : Pfam (NCBI) | pfam00041 pfam07679 pfam00612 pfam00069 pfam00621 |
Domain families : Smart (EMBL) | FN3 (SM00060) IG (SM00409) IGc2 (SM00408) IGv (SM00406) IQ (SM00015) PH (SM00233) RhoGEF (SM00325) S_TKc (SM00220) |
Conserved Domain (NCBI) | OBSCN |
Blocks (Seattle) | OBSCN |
PDB (RSDB) | 1V1C 2CR6 2DKU 2DM7 2E7B 2EDF 2EDH 2EDL 2EDQ 2EDR 2EDT 2EDW 2ENY 2EO1 2GQH 2MWC 2N56 2YZ8 4C4K 4RSV 4UOW 5TZM 6MG9 |
PDB Europe | 1V1C 2CR6 2DKU 2DM7 2E7B 2EDF 2EDH 2EDL 2EDQ 2EDR 2EDT 2EDW 2ENY 2EO1 2GQH 2MWC 2N56 2YZ8 4C4K 4RSV 4UOW 5TZM 6MG9 |
PDB (PDBSum) | 1V1C 2CR6 2DKU 2DM7 2E7B 2EDF 2EDH 2EDL 2EDQ 2EDR 2EDT 2EDW 2ENY 2EO1 2GQH 2MWC 2N56 2YZ8 4C4K 4RSV 4UOW 5TZM 6MG9 |
PDB (IMB) | 1V1C 2CR6 2DKU 2DM7 2E7B 2EDF 2EDH 2EDL 2EDQ 2EDR 2EDT 2EDW 2ENY 2EO1 2GQH 2MWC 2N56 2YZ8 4C4K 4RSV 4UOW 5TZM 6MG9 |
Structural Biology KnowledgeBase | 1V1C 2CR6 2DKU 2DM7 2E7B 2EDF 2EDH 2EDL 2EDQ 2EDR 2EDT 2EDW 2ENY 2EO1 2GQH 2MWC 2N56 2YZ8 4C4K 4RSV 4UOW 5TZM 6MG9 |
SCOP (Structural Classification of Proteins) | 1V1C 2CR6 2DKU 2DM7 2E7B 2EDF 2EDH 2EDL 2EDQ 2EDR 2EDT 2EDW 2ENY 2EO1 2GQH 2MWC 2N56 2YZ8 4C4K 4RSV 4UOW 5TZM 6MG9 |
CATH (Classification of proteins structures) | 1V1C 2CR6 2DKU 2DM7 2E7B 2EDF 2EDH 2EDL 2EDQ 2EDR 2EDT 2EDW 2ENY 2EO1 2GQH 2MWC 2N56 2YZ8 4C4K 4RSV 4UOW 5TZM 6MG9 |
Superfamily | Q5VST9 |
Human Protein Atlas [tissue] | ENSG00000154358-OBSCN [tissue] |
Peptide Atlas | Q5VST9 |
HPRD | 08594 |
IPI | IPI00288940 IPI00742748 IPI00744119 IPI00479915 IPI00854629 IPI00953396 IPI00016383 IPI00641787 |
| Protein Interaction databases |
DIP (DOE-UCLA) | Q5VST9 |
IntAct (EBI) | Q5VST9 |
BioGRID | OBSCN |
STRING (EMBL) | OBSCN |
ZODIAC | OBSCN |
| Ontologies - Pathways |
QuickGO | Q5VST9 |
Ontology : AmiGO | protein serine/threonine kinase activity guanyl-nucleotide exchange factor activity protein binding calmodulin binding ATP binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-3,4,5-trisphosphate binding cytosol cytosol plasma membrane protein phosphorylation G protein-coupled receptor signaling pathway multicellular organism development structural constituent of muscle phosphatidylinositol-5-phosphate binding nuclear body myofibril Z disc ankyrin binding M band titin binding phosphatidylinositol-3-phosphate binding protein localization to M-band sarcolemma positive regulation of apoptotic process phosphatidylinositol-3,4-bisphosphate binding sarcomere organization metal ion binding regulation of small GTPase mediated signal transduction phosphatidylinositol-4-phosphate binding |
Ontology : EGO-EBI | protein serine/threonine kinase activity guanyl-nucleotide exchange factor activity protein binding calmodulin binding ATP binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-3,4,5-trisphosphate binding cytosol cytosol plasma membrane protein phosphorylation G protein-coupled receptor signaling pathway multicellular organism development structural constituent of muscle phosphatidylinositol-5-phosphate binding nuclear body myofibril Z disc ankyrin binding M band titin binding phosphatidylinositol-3-phosphate binding protein localization to M-band sarcolemma positive regulation of apoptotic process phosphatidylinositol-3,4-bisphosphate binding sarcomere organization metal ion binding regulation of small GTPase mediated signal transduction phosphatidylinositol-4-phosphate binding |
NDEx Network | OBSCN |
Atlas of Cancer Signalling Network | OBSCN |
Wikipedia pathways | OBSCN |
| Orthology - Evolution |
OrthoDB | 84033 |
GeneTree (enSembl) | ENSG00000154358 |
Phylogenetic Trees/Animal Genes : TreeFam | OBSCN |
HOGENOM | Q5VST9 |
Homologs : HomoloGene | OBSCN |
Homology/Alignments : Family Browser (UCSC) | OBSCN |
| Gene fusions - Rearrangements |
Fusion : Mitelman | OBSCN/CASZ1 [1q42.13/1p36.22]   |
Fusion : Mitelman | OBSCN/DISC1 [1q42.13/1q42.2]   |
Fusion : Mitelman | OBSCN/IGSF21 [1q42.13/1p36.13]   |
Fusion : Mitelman | RNF187/OBSCN [1q42.13/1q42.13]   |
Fusion Portal | OBSCN 1q42.13 CASZ1 1p36.22 HNSC |
Fusion Portal | OBSCN 1q42.13 DISC1 1q42.2 SKCM |
Fusion Portal | OBSCN 1q42.13 IGSF21 1p36.13 BRCA |
Fusion : Quiver | OBSCN |
| Polymorphisms : SNP and Copy number variants |
NCBI Variation Viewer | OBSCN [hg38] |
dbVar | OBSCN |
ClinVar | OBSCN |
Monarch | OBSCN |
1000_Genomes | OBSCN |
Exome Variant Server | OBSCN |
GNOMAD Browser | ENSG00000154358 |
Varsome Browser | OBSCN |
Genomic Variants (DGV) | OBSCN [DGVbeta] |
DECIPHER | OBSCN [patients] [syndromes] [variants] [genes] |
CONAN: Copy Number Analysis | OBSCN |
| Mutations |
ICGC Data Portal | OBSCN |
TCGA Data Portal | OBSCN |
Broad Tumor Portal | OBSCN |
OASIS Portal | OBSCN [ Somatic mutations - Copy number] |
Somatic Mutations in Cancer : COSMIC | OBSCN [overview] [genome browser] [tissue] [distribution] |
Somatic Mutations in Cancer : COSMIC3D | OBSCN |
Mutations and Diseases : HGMD | OBSCN |
LOVD (Leiden Open Variation Database) | Whole genome datasets |
LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
BioMuta | search OBSCN |
DgiDB (Drug Gene Interaction Database) | OBSCN |
DoCM (Curated mutations) | OBSCN (select the gene name) |
CIViC (Clinical Interpretations of Variants in Cancer) | OBSCN (select a term) |
intoGen | OBSCN |
Cancer3D | OBSCN(select the gene name) |
Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
---|
OMIM | 608616 |
Orphanet | |
DisGeNET | OBSCN |
Medgen | OBSCN |
Genetic Testing Registry | OBSCN
|
NextProt | Q5VST9 [Medical] |
GENETests | OBSCN |
Target Validation | OBSCN |
Huge Navigator |
OBSCN [HugePedia] |
ClinGen | OBSCN |
| Clinical trials, drugs, therapy |
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MyCancerGenome | OBSCN |
Protein Interactions : CTD | |
Pharm GKB Gene | PA31888 |
Pharos | Q5VST9 |
Clinical trial | OBSCN |
| Miscellaneous |
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canSAR (ICR) | OBSCN (select the gene name) |
Harmonizome | OBSCN |
DataMed Index | OBSCN |
| Probes |
---|
| Litterature |
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PubMed | 62 Pubmed reference(s) in Entrez |
GeneRIFs | Gene References Into Functions (Entrez) |
EVEX | OBSCN |