ODAM (odontogenic, ameloblast associated)

2007-02-01  

Identity

HGNC
ODAM
LOCATION
4q13.3
LOCUSID
54959
ALIAS
APIN

Other Information

Locus ID:

NCBI: 54959
MIM: 614843
HGNC: 26043
Ensembl: ENSG00000109205

Variants:

dbSNP: 54959
ClinVar: 54959
TCGA: ENSG00000109205
COSMIC: ODAM

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109205ENST00000396094A1E959
ENSG00000109205ENST00000510709D6RA81
ENSG00000109205ENST00000510847H0Y8T7
ENSG00000109205ENST00000514097H0YA46

Expression (GTEx)

0
100
200
300
400
500
600
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Amyloid fiber formationREACTOMER-HSA-977225

References

Pubmed IDYearTitleCitations
176472622008Characterization of Apin, a secreted protein highly expressed in tooth-associated epithelia.34
184729692008Expression of odontogenic ameloblast-associated protein (ODAM) in dental and other epithelial neoplasms.20
184843352008Odontogenic ameloblast-associated protein nature of the amyloid found in calcifying epithelial odontogenic tumors and unerupted tooth follicles.12
146470392003Calcifying epithelial odontogenic (Pindborg) tumor-associated amyloid consists of a novel human protein.11
205729172010Disruption of periodontal integrity induces expression of apin by epithelial cell rests of Malassez.11
223871952012Expression pattern, subcellular localization, and functional implications of ODAM in ameloblasts, odontoblasts, osteoblasts, and various cancer cells.10
236481482013Odontogenic ameloblast-associated protein (ODAM) inhibits growth and migration of human melanoma cells and elicits PTEN elevation and inactivation of PI3K/AKT signaling.4
276940042016Odontogenic ameloblast-associated protein (ODAM) inhibits human colorectal cancer growth by promoting PTEN elevation and inactivating PI3K/AKT signaling.4
297458112018The enamel protein ODAM promotes mineralization in a collagen matrix.4
263583982015ODAM inhibits RhoA-dependent invasion in breast cancer.3

Citation

Dessen P

ODAM (odontogenic, ameloblast associated)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43580/odam