ODC1 (ornithine decarboxylase 1)

2003-08-01  

Identity

HGNC
LOCATION
2p25.1
LOCUSID
ALIAS
BABS,NEDBA,NEDBIA,ODC
FUSION GENES

Other Information

Locus ID:

NCBI: 4953
MIM: 165640
HGNC: 8109
Ensembl: ENSG00000115758

Variants:

dbSNP: 4953
ClinVar: 4953
TCGA: ENSG00000115758
COSMIC: ODC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115758ENST00000234111P11926
ENSG00000115758ENST00000405333P11926
ENSG00000115758ENST00000443218C9JG30

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Arginine and proline metabolismKEGGko00330
Glutathione metabolismKEGGko00480
Arginine and proline metabolismKEGGhsa00330
Glutathione metabolismKEGGhsa00480
Metabolic pathwaysKEGGhsa01100
Polyamine biosynthesis, arginine => ornithine => putrescineKEGGhsa_M00134
Polyamine biosynthesis, arginine => ornithine => putrescineKEGGM00134
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Metabolism of polyaminesREACTOMER-HSA-351202
Regulation of ornithine decarboxylase (ODC)REACTOMER-HSA-350562

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA446108Colorectal NeoplasmsDiseaseVariantAnnotationnot associatedPD
PA448497aspirinChemicalVariantAnnotationnot associatedPD

References

Pubmed IDYearTitleCitations
164593312006Regulation of ornithine decarboxylase.126
190471522008ODC1 is a critical determinant of MYCN oncogenesis and a therapeutic target in neuroblastoma.68
128109522003Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene.53
206000192010Polyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide Production.41
239175842013Metabolic profiling of Alzheimer's disease brains.26
264609452015Non-canonical Hedgehog/AMPK-Mediated Control of Polyamine Metabolism Supports Neuronal and Medulloblastoma Cell Growth.24
199604352010The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification.22
155341042004Loss of methylthioadenosine phosphorylase and elevated ornithine decarboxylase is common in pancreatic cancer.19
170471982006Ornithine decarboxylase polymorphism modification of response to aspirin treatment for colorectal adenoma prevention.19
197893102009Associations of a polymorphism in the ornithine decarboxylase gene with colorectal cancer survival.18

Citation

Dessen P

ODC1 (ornithine decarboxylase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41603/odc1