OGA (O-GlcNAcase)

2018-07-01  

Identity

HGNC
OGA
LOCATION
10q24.32
LOCUSID
10724
ALIAS
MEA5,MGEA5,NCOAT

Other Information

Locus ID:

NCBI: 10724
MIM: 604039
HGNC: 7056
Ensembl: ENSG00000198408

Variants:

dbSNP: 10724
ClinVar: 10724
TCGA: ENSG00000198408
COSMIC: OGA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198408ENST00000357797O60502
ENSG00000198408ENST00000361464O60502
ENSG00000198408ENST00000370094O60502
ENSG00000198408ENST00000429860H7C3X0
ENSG00000198408ENST00000439817O60502

Pathways

PathwaySourceExternal ID
Insulin resistanceKEGGhsa04931

References

Pubmed IDYearTitleCitations
111482102001Dynamic O-glycosylation of nuclear and cytosolic proteins: cloning and characterization of a neutral, cytosolic beta-N-acetylglucosaminidase from human brain.185
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
214715142011O-GlcNAcylation increases ChREBP protein content and transcriptional activity in the liver.64
215671372012Gene expression of O-GlcNAc cycling enzymes in human breast cancers.41
223119712012Insights into O-linked N-acetylglucosamine ([0-9]O-GlcNAc) processing and dynamics through kinetic analysis of O-GlcNAc transferase and O-GlcNAcase activity on protein substrates.33
227303282012O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) in primary and metastatic colorectal cancer clones and effect of N-acetyl-β-D-glucosaminidase silencing on cell phenotype and transcriptome.33
227835922012Prediction of bladder cancer based on urinary content of MGEA5 and OGT mRNA level.28
251830112014MicroRNA-539 is up-regulated in failing heart, and suppresses O-GlcNAcase expression.24
251737362014O-GlcNAc transferase and O-GlcNAcase: achieving target substrate specificity.23
208632792010Human OGA binds substrates in a conserved peptide recognition groove.21

Citation

Dessen P

OGA (O-GlcNAcase)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57432/oga