OLA1 (Obg like ATPase 1)

2010-02-01  

Identity

HGNC
OLA1
LOCATION
2q31.1
LOCUSID
29789
ALIAS
DOC45,GBP45,GTBP9,GTPBP9,PTD004
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 29789
MIM: 611175
HGNC: 28833
Ensembl: ENSG00000138430

Variants:

dbSNP: 29789
ClinVar: 29789
TCGA: ENSG00000138430
COSMIC: OLA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138430ENST00000284719Q9NTK5
ENSG00000138430ENST00000344357Q9NTK5
ENSG00000138430ENST00000409546J3KQ32
ENSG00000138430ENST00000427472C9JTK6
ENSG00000138430ENST00000428402Q9NTK5
ENSG00000138430ENST00000429575C9JCJ9

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
197064042009OLA1, an Obg-like ATPase, suppresses antioxidant response via nontranscriptional mechanisms.26
242899232014The BRCA1/BARD1-interacting protein OLA1 functions in centrosome regulation.22
234123842013OLA1 protects cells in heat shock by stabilizing HSP70.21
198827532009Knockdown of OLA1, a regulator of oxidative stress response, inhibits motility and invasion of breast cancer cells.16
262831792015OLA1 regulates protein synthesis and integrated stress response by inhibiting eIF2 ternary complex formation.16
200537272010DOC45, a novel DNA damage-regulated nucleocytoplasmic ATPase that is overexpressed in multiple human malignancies.15
268634552016OLA1 contributes to epithelial-mesenchymal transition in lung cancer by modulating the GSK3β/snail/E-cadherin signaling.7
244864882014Regulation of cell-matrix adhesion by OLA1, the Obg-like ATPase 1.6
185369992008The identification and characterization of a new GTP-binding protein (Gbp45) involved in cell proliferation and death related to mitochondrial function.5

Citation

Dessen P

OLA1 (Obg like ATPase 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-02-01

Online version: http://atlasgeneticsoncology.org/gene/51328/ola1