OLR1 (oxidized low density lipoprotein receptor 1)

2011-10-01  

Identity

HGNC
LOCATION
12p13.2
LOCUSID
ALIAS
CLEC8A,LOX1,LOXIN,SCARE1,SLOX1
FUSION GENES

Other Information

Locus ID:

NCBI: 4973
MIM: 602601
HGNC: 8133
Ensembl: ENSG00000173391

Variants:

dbSNP: 4973
ClinVar: 4973
TCGA: ENSG00000173391
COSMIC: OLR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173391ENST00000309539P78380
ENSG00000173391ENST00000309539A0A024RAU0
ENSG00000173391ENST00000339968J3QTI8
ENSG00000173391ENST00000432556P78380
ENSG00000173391ENST00000538745F5H3G7
ENSG00000173391ENST00000538873F5H0N6
ENSG00000173391ENST00000539518F5H7N8
ENSG00000173391ENST00000543414F5H001
ENSG00000173391ENST00000543993B7ZAN8
ENSG00000173391ENST00000544577F5GZH1
ENSG00000173391ENST00000545927P78380

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
PPAR signaling pathwayKEGGko03320
PPAR signaling pathwayKEGGhsa03320
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Neutrophil degranulationREACTOMER-HSA-6798695

References

Pubmed IDYearTitleCitations
123543872002Involvement of LOX-1 in dendritic cell-mediated antigen cross-presentation.137
226412162013Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK.86
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
160617452005Serum soluble lectin-like oxidized low-density lipoprotein receptor-1 levels are elevated in acute coronary syndrome: a novel marker for early diagnosis.58
150015262004Glucose enhances human macrophage LOX-1 expression: role for LOX-1 in glucose-induced macrophage foam cell formation.44
177172932007Small concentrations of oxLDL induce capillary tube formation from endothelial cells via LOX-1-dependent redox-sensitive pathway.39
191508832009Mediation of electronegative low-density lipoprotein signaling by LOX-1: a possible mechanism of endothelial apoptosis.39
211304562011OxLDL-dependent activation of arginase II is dependent on the LOX-1 receptor and downstream RhoA signaling.39
160139132005A cluster of cholesterol-related genes confers susceptibility for Alzheimer's disease.38

Citation

Dessen P

OLR1 (oxidized low density lipoprotein receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2011-10-01

Online version: http://atlasgeneticsoncology.org/gene/52401/olr1