OMA1 (OMA1 zinc metallopeptidase)

2014-01-01  

Identity

HGNC
OMA1
LOCATION
1p32.2
LOCUSID
115209
ALIAS
2010001O09Rik,DAB1,MPRP-1,MPRP1,YKR087C,ZMPOMA1,peptidase
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 115209
MIM: 617081
HGNC: 29661
Ensembl: ENSG00000162600

Variants:

dbSNP: 115209
ClinVar: 115209
TCGA: ENSG00000162600
COSMIC: OMA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162600ENST00000371226Q96E52
ENSG00000162600ENST00000419242X6RIG5
ENSG00000162600ENST00000421528H7BZX2
ENSG00000162600ENST00000426139X6RL62
ENSG00000162600ENST00000453710X6RD49
ENSG00000162600ENST00000456980X6RDQ1
ENSG00000162600ENST00000482274S4R3A3

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Regulation of ApoptosisREACTOMER-HSA-169911

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
200386772009Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells.172
176152982007OPA1 processing reconstituted in yeast depends on the subunit composition of the m-AAA protease in mitochondria.58
252750092014Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis.47
246345142014Impaired OMA1-dependent cleavage of OPA1 and reduced DRP1 fission activity combine to prevent mitophagy in cells that are dependent on oxidative phosphorylation.43
269235992016Reciprocal Degradation of YME1L and OMA1 Adapts Mitochondrial Proteolytic Activity during Stress.42
247192242014Membrane depolarization activates the mitochondrial protease OMA1 by stimulating self-cleavage.37
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
251128772014p53 is required for cisplatin-induced processing of the mitochondrial fusion protein L-Opa1 that is mediated by the mitochondrial metallopeptidase Oma1 in gynecologic cancers.17
295455052018m-AAA and i-AAA complexes coordinate to regulate OMA1, the stress-activated supervisor of mitochondrial dynamics.10
307331182019Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK1.9

Citation

Dessen P

OMA1 (OMA1 zinc metallopeptidase)

Atlas Genet Cytogenet Oncol Haematol. 2014-01-01

Online version: http://atlasgeneticsoncology.org/gene/53667/oma1