OPN4 (opsin 4)

2014-11-01  

Identity

HGNC
LOCATION
10q23.2
LOCUSID
ALIAS
MOP

Other Information

Locus ID:

NCBI: 94233
MIM: 606665
HGNC: 14449
Ensembl: ENSG00000122375

Variants:

dbSNP: 94233
ClinVar: 94233
TCGA: ENSG00000122375
COSMIC: OPN4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122375ENST00000241891Q9UHM6
ENSG00000122375ENST00000372071Q9UHM6
ENSG00000122375ENST00000443292C9JWU6

Expression (GTEx)

0
1
2
3
4

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
OpsinsREACTOMER-HSA-419771
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
157169532005Melanopsin-expressing ganglion cells in primate retina signal colour and irradiance and project to the LGN.355
156742442005Addition of human melanopsin renders mammalian cells photoresponsive.103
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
235543932013Human melanopsin forms a pigment maximally sensitive to blue light (λmax ≈ 479 nm) supporting activation of G(q/11) and G(i/o) signalling cascades.68
230554932012Melanopsin and rod-cone photoreceptors play different roles in mediating pupillary light responses during exposure to continuous light in humans.61
253130402014Opponent melanopsin and S-cone signals in the human pupillary light response.51
208103192010The emerging roles of melanopsin in behavioral adaptation to light.50
188042842009A missense variant (P10L) of the melanopsin (OPN4) gene in seasonal affective disorder.45
188042842009A missense variant (P10L) of the melanopsin (OPN4) gene in seasonal affective disorder.45
205546942010Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption.45

Citation

Dessen P

OPN4 (opsin 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71135/opn4