OPRD1 (opioid receptor delta 1)

2010-06-01  

Identity

HGNC
OPRD1
LOCATION
1p35.3
LOCUSID
4985
ALIAS
DOP,DOR,DOR1,OPRD

Other Information

Locus ID:

NCBI: 4985
MIM: 165195
HGNC: 8153
Ensembl: ENSG00000116329

Variants:

dbSNP: 4985
ClinVar: 4985
TCGA: ENSG00000116329
COSMIC: OPRD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116329ENST00000234961P41143
ENSG00000116329ENST00000621425D2CGC9

Expression (GTEx)

0
1
2
3
4
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443309AlcoholismDiseaseClinicalAnnotationassociatedPD22954510
PA444460Heroin DependenceDiseaseClinicalAnnotation, VariantAnnotationambiguousPD28692418
PA445043Opioid-Related DisordersDiseaseClinicalAnnotationassociatedPD23612435, 24126707, 30368523, 30549211
PA446878Cocaine-Related DisordersDiseaseClinicalAnnotationassociatedPD
PA447218Sexual Dysfunctions, PsychologicalDiseaseClinicalAnnotationassociatedPD30549211
PA448685buprenorphineChemicalClinicalAnnotationassociatedPD23612435, 24126707, 30368523, 30549211
PA449072cocaineChemicalClinicalAnnotationassociatedPD
PA449599fentanylChemicalClinicalAnnotationassociatedPD30549211
PA450401methadoneChemicalClinicalAnnotationassociatedPKPD31907389
PA450588naltrexoneChemicalClinicalAnnotationassociatedPD22954510
PA450741oxycodoneChemicalClinicalAnnotationassociatedPD
PA451735tramadolChemicalClinicalAnnotationassociatedPD30549211
PA452618opioidsChemicalClinicalAnnotationassociated
PA452619heroinChemicalClinicalAnnotation, VariantAnnotationambiguousPD28692418

References

Pubmed IDYearTitleCitations
244133992014Molecular control of δ-opioid receptor signalling.160
185189252008Genetic susceptibility to heroin addiction: a candidate gene association study.99
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
173740342007Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA Cooperative Study.84
176222222008The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk.68
176222222008The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk.68
210796072011A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa.67
210796072011A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa.67
182004972008Ligand stabilization of CXCR4/delta-opioid receptor heterodimers reveals a mechanism for immune response regulation.55
124138852002Interactions of opioid and chemokine receptors: oligomerization of mu, kappa, and delta with CCR5 on immune cells.38

Citation

Dessen P

OPRD1 (opioid receptor delta 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-06-01

Online version: http://atlasgeneticsoncology.org/gene/51518/oprd1