OPRK1 (opioid receptor kappa 1)

2007-11-01  

Identity

HGNC
LOCATION
8q11.23
LOCUSID
ALIAS
K-OR-1,KOP,KOR,KOR-1,KOR1,OPRK

Other Information

Locus ID:

NCBI: 4986
MIM: 165196
HGNC: 8154
Ensembl: ENSG00000082556

Variants:

dbSNP: 4986
ClinVar: 4986
TCGA: ENSG00000082556
COSMIC: OPRK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000082556ENST00000265572P41145
ENSG00000082556ENST00000520287P41145
ENSG00000082556ENST00000522508E5RJI5
ENSG00000082556ENST00000524278P41145
ENSG00000082556ENST00000612786P41145
ENSG00000082556ENST00000613482A0A087WU84

Expression (GTEx)

0
1
2
3
4
5

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA166128095treatment failureDiseaseVariantAnnotationassociatedPD27472837
PA443309AlcoholismDiseaseClinicalAnnotationassociatedPD
PA444460Heroin DependenceDiseaseClinicalAnnotationassociatedPD17373729, 31940240
PA445043Opioid-Related DisordersDiseaseVariantAnnotationnot associated
PA445062NeoplasmsDiseaseClinicalAnnotation, VariantAnnotationassociatedPD27472837, 29259946
PA445208PainDiseaseClinicalAnnotation, VariantAnnotationassociatedPD27472837, 29259946
PA448073ethanolChemicalClinicalAnnotationassociatedPD
PA450401methadoneChemicalClinicalAnnotationassociatedPD31940240
PA450550morphineChemicalClinicalAnnotationassociatedPD29259946
PA450741oxycodoneChemicalVariantAnnotationassociatedPD27472837
PA452618opioidsChemicalMultilinkAnnotation, VariantAnnotationambiguous27139154
PA452619heroinChemicalClinicalAnnotationassociatedPD17373729

References

Pubmed IDYearTitleCitations
224375042012Structure of the human κ-opioid receptor in complex with JDTic.300
185189252008Genetic susceptibility to heroin addiction: a candidate gene association study.99
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
177027502007Long-acting kappa opioid antagonists disrupt receptor signaling and produce noncompetitive effects by activating c-Jun N-terminal kinase.85
173740342007Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA Cooperative Study.84
198047962009kappa-Opioid receptor signaling and brain reward function.71
176222222008The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk.68
176222222008The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk.68
169242692006Association of the kappa-opioid system with alcohol dependence.64
169242692006Association of the kappa-opioid system with alcohol dependence.64

Citation

Dessen P

OPRK1 (opioid receptor kappa 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-11-01

Online version: http://atlasgeneticsoncology.org/gene/49809/oprk1