OPRM1 (opioid receptor mu 1)

2008-04-01  

Identity

HGNC
OPRM1
LOCATION
6q25.2
LOCUSID
4988
ALIAS
LMOR,M-OR-1,MOP,MOR,MOR1,OPRM

Other Information

Locus ID:

NCBI: 4988
MIM: 600018
HGNC: 8156
Ensembl: ENSG00000112038

Variants:

dbSNP: 4988
ClinVar: 4988
TCGA: ENSG00000112038
COSMIC: OPRM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112038ENST00000229768P35372
ENSG00000112038ENST00000330432P35372
ENSG00000112038ENST00000337049P35372
ENSG00000112038ENST00000360422L0E130
ENSG00000112038ENST00000414028P35372
ENSG00000112038ENST00000419506P35372
ENSG00000112038ENST00000428397P35372
ENSG00000112038ENST00000434900P35372
ENSG00000112038ENST00000435918P35372
ENSG00000112038ENST00000452687P35372
ENSG00000112038ENST00000518759P35372
ENSG00000112038ENST00000519083P35372
ENSG00000112038ENST00000520282E7EW71
ENSG00000112038ENST00000520708P35372
ENSG00000112038ENST00000522236P35372
ENSG00000112038ENST00000522555P35372
ENSG00000112038ENST00000522739P35372
ENSG00000112038ENST00000524150P35372
ENSG00000112038ENST00000524163P35372

Expression (GTEx)

0
1
2
3
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Morphine addictionKEGGhsa05032
Morphine addictionKEGGko05032
Estrogen signaling pathwayKEGGhsa04915
Estrogen signaling pathwayKEGGko04915
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
Opioid SignallingREACTOMER-HSA-111885
G-protein activationREACTOMER-HSA-202040
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10402benzodiazepine derivativesChemicalClinicalAnnotationassociatedPD
PA131890620cannabinoidsChemicalClinicalAnnotationassociatedPD11840318, 31246565
PA162263525neuropathic painDiseaseClinicalAnnotationassociatedPD21837673
PA164712362AnalgesicsChemicalClinicalAnnotationassociated25096645
PA164712462Antiinflammatory agents, non-steroidsChemicalClinicalAnnotationassociated25096645
PA164712720Drugs used in nicotine dependenceChemicalClinicalAnnotationassociatedPD15007373, 17224915
PA164712741Ergot alkaloidsChemicalClinicalAnnotationassociated25096645
PA164712948Opioid anestheticsChemicalClinicalAnnotationassociatedPD30136624
PA164713083Other general anestheticsChemicalClinicalAnnotationassociatedPD30136624
PA164713301SympathomimeticsChemicalClinicalAnnotationassociatedPD
PA166114414cotinineChemicalClinicalAnnotationassociatedPK23223006
PA166119022methamphetamine dependenceDiseaseClinicalAnnotationassociatedPD16402083
PA166123307insomniaDiseaseClinicalAnnotationassociatedPD31745220
PA166129521sedationDiseaseClinicalAnnotationassociatedPD31745220
PA166131630volatile anestheticsChemicalClinicalAnnotationassociatedPD30136624
PA166151827adverse eventsDiseaseClinicalAnnotationassociatedPD19683391, 25794200, 30549211, 31337162, 31745220
PA166177229highly active antiretroviral therapy (haart)ChemicalClinicalAnnotationassociatedPD
PA166185626somnolenceDiseaseClinicalAnnotationassociatedPD30281924
PA166186039suicidal ideationDiseaseClinicalAnnotationassociatedPD
PA166186040tianeptineChemicalClinicalAnnotationassociatedPD
PA443309AlcoholismDiseaseClinicalAnnotation, VariantAnnotationambiguousPD10490697, 11424981, 11522434, 15252283, 15525999, 15902904, 16387451, 16679777, 19891732, 21039637, 21946895, 22071118, 22515274, 23254216, 24035285, 25410894, 25715171, 25760804, 27447243, 30322771, 31961981, 32020635, 9399694
PA443602Marijuana AbuseDiseaseClinicalAnnotationassociatedPD
PA444365Heart ArrestDiseaseClinicalAnnotationassociatedPD
PA444460Heroin DependenceDiseaseClinicalAnnotation, VariantAnnotationambiguousPD11338173, 11424981, 11933204, 12657887, 19891732, 23651024, 23651028, 28692418
PA445043Opioid-Related DisordersDiseaseClinicalAnnotationassociatedPD12960749, 16387451, 23651024, 30549211, 31853823
PA445048NauseaDiseaseClinicalAnnotation, VariantAnnotationambiguousPD19683391, 24858579, 25794200, 31337162, 31745220
PA445204Ovarian NeoplasmsDiseaseClinicalAnnotationassociatedPD23963862
PA445208PainDiseaseClinicalAnnotation, VariantAnnotationambiguousPKPD16580900, 16871067, 16879459, 16906017, 17898703, 19514130, 19605407, 19683391, 19783098, 20003118, 20171873, 21150856, 21209234, 21398039, 22153130, 23302985, 23313934, 23557865, 23592691, 23686330, 23803057, 23909491, 24703092, 25102313, 25155931, 25239082, 25794200, 26902643, 27649267, 28379874, 28591085, 28745577, 29474345, 29601950, 31337162, 31773688
PA445210Pain, PostoperativeDiseaseClinicalAnnotation, VariantAnnotationambiguousPD16580900, 16871067, 16879459, 17898703, 19514130, 19683391, 20003118, 21150856, 21209234, 21398039, 22230405, 23313934, 23557865, 23686330, 23803057, 23909491, 24703092, 24858579, 25102313, 25155931, 25239082, 25794200, 26902643, 27649267, 28379874, 28591085, 28745577, 29474345, 29601950, 31337162, 31773688
PA445437PruritusDiseaseClinicalAnnotationassociatedPD28591085
PA445522Respiratory InsufficiencyDiseaseClinicalAnnotationassociatedPD
PA445768Substance Withdrawal SyndromeDiseaseClinicalAnnotationassociated25096645
PA445876Tobacco Use DisorderDiseaseClinicalAnnotation, VariantAnnotationassociatedPD15007373, 16387451, 16960700, 17224915, 31206155
PA446051VomitingDiseaseClinicalAnnotation, VariantAnnotationambiguousPD19683391, 24858579, 25794200, 31337162, 31745220
PA446199OverdoseDiseaseClinicalAnnotationassociatedPD
PA446876Substance-Related DisordersDiseaseClinicalAnnotationassociatedPD11840318, 31246565
PA446878Cocaine-Related DisordersDiseaseClinicalAnnotationassociatedPD16387451
PA447230HIV InfectionsDiseaseClinicalAnnotationassociatedPD
PA447321Depressive Disorder, MajorDiseaseClinicalAnnotationassociatedPD
PA448015acetaminophenChemicalClinicalAnnotationassociatedPD21837673
PA448073ethanolChemicalClinicalAnnotation, VariantAnnotationambiguousPD10490697, 11424981, 11522434, 11840318, 15252283, 15525999, 15608594, 15902904, 16387451, 16679777, 17339526, 19891732, 21039637, 22071118, 22260295, 22436571, 22798433, 23254216, 24035285, 24134200, 25215437, 25836994, 25937240, 27447243, 30322771, 31246565, 9399694
PA448084alfentanilChemicalClinicalAnnotationassociatedPKPD16906017, 19605407
PA448408amphetamineChemicalClinicalAnnotationassociatedPD
PA448685buprenorphineChemicalClinicalAnnotationassociatedPD30549211
PA448803carboplatinChemicalClinicalAnnotationassociatedPD23963862
PA449072cocaineChemicalClinicalAnnotationassociatedPD11840318, 16387451, 31246565
PA449088codeineChemicalClinicalAnnotationassociatedPD25752520
PA449383docetaxelChemicalClinicalAnnotationassociatedPD23963862
PA449599fentanylChemicalClinicalAnnotation, VariantAnnotationambiguousPD19514130, 19783098, 20003118, 20171873, 21150856, 23302985, 23313934, 23557865, 23592691, 23909491, 24858579, 29601950, 30281924, 30549211
PA449900hydrocodoneChemicalClinicalAnnotationassociatedPD23703421
PA450401methadoneChemicalClinicalAnnotation, VariantAnnotationambiguousPD23651024
PA450403methamphetamineChemicalClinicalAnnotationassociatedPD16402083
PA450550morphineChemicalClinicalAnnotation, VariantAnnotationambiguousPKPD15086512, 16580900, 16871067, 16879459, 17898703, 19514130, 23686330, 24703092, 24747667, 25155931, 26902643, 27649267, 28591085, 29474345
PA450586naloxoneChemicalClinicalAnnotationassociatedPD11751037, 12627468, 16123758, 18004207
PA450588naltrexoneChemicalClinicalAnnotationassociatedPD16960700, 21946895, 22515274, 25410894, 25715171, 25760804, 31206155, 31961981, 32020635
PA450626nicotineChemicalClinicalAnnotation, VariantAnnotationassociatedPKPD11840318, 15007373, 16387451, 16960700, 17224915, 22260295, 23223006, 31246565
PA450741oxycodoneChemicalClinicalAnnotationassociatedPD21209234, 25239082, 31773688
PA450761paclitaxelChemicalClinicalAnnotationassociatedPD23963862
PA451527sufentanilChemicalClinicalAnnotationassociatedPD22153130, 31773688
PA451566sumatriptanChemicalClinicalAnnotationassociated25096645
PA451735tramadolChemicalClinicalAnnotationassociatedPD21837673, 30549211
PA452229antidepressantsChemicalClinicalAnnotationassociatedPD
PA452233antipsychoticsChemicalClinicalAnnotationassociatedPD
PA452618opioidsChemicalClinicalAnnotation, MultilinkAnnotation, VariantAnnotationambiguousPD11840318, 12960749, 16387451, 19683391, 21398039, 22230405, 23803057, 25096645, 25102313, 25794200, 27139154, 28379874, 28745577, 31246565, 31337162, 31745220, 31853823
PA452619heroinChemicalClinicalAnnotationassociatedPD11338173, 11424981, 11933204, 12657887, 19891732, 23651028, 28692418, 31853823
PA452633morphine-6-glucuronideChemicalVariantAnnotationnot associated15086512

References

Pubmed IDYearTitleCitations
160463952005Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G.209
128134722003A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients.193
175789172007Placebo effects on human mu-opioid activity during pain.193
182502512008An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study.170
182502512008An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study.170
156085942004A polymorphism of the mu-opioid receptor gene (OPRM1) and sensitivity to the effects of alcohol in humans.130
178556142007Decreased central mu-opioid receptor availability in fibromyalgia.128
204797552011A genetic determinant of the striatal dopamine response to alcohol in men.120
177682722007Effects of naltrexone on alcohol sensitivity and genetic moderators of medication response: a double-blind placebo-controlled study.113
157729092005The A118G single nucleotide polymorphism of the mu-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans.108

Citation

Dessen P

OPRM1 (opioid receptor mu 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-04-01

Online version: http://atlasgeneticsoncology.org/gene/50098/oprm1