ORAI1 (ORAI calcium release-activated calcium modulator 1)

2007-02-01  

Identity

HGNC
LOCATION
12q24.31
LOCUSID
ALIAS
CRACM1,IMD9,ORAT1,TAM2,TMEM142A

Other Information

Locus ID:

NCBI: 84876
MIM: 610277
HGNC: 25896

Variants:

dbSNP: 84876
ClinVar: 84876
COSMIC: ORAI1

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Primary immunodeficiencyKEGGko05340
Calcium signaling pathwayKEGGhsa04020
Primary immunodeficiencyKEGGhsa05340
Platelet activationKEGGhsa04611
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Renin secretionKEGGhsa04924
Renin secretionKEGGko04924
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Signaling by the B Cell Receptor (BCR)REACTOMER-HSA-983705
Antigen activates B Cell Receptor (BCR) leading to generation of second messengersREACTOMER-HSA-983695
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Platelet calcium homeostasisREACTOMER-HSA-418360
Elevation of cytosolic Ca2+ levelsREACTOMER-HSA-139853
Muscle contractionREACTOMER-HSA-397014
Aldosterone synthesis and secretionKEGGhsa04925
Aldosterone synthesis and secretionKEGGko04925
Cardiac conductionREACTOMER-HSA-5576891
Ion homeostasisREACTOMER-HSA-5578775

Protein levels

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
380200662024Neutrophil-specific ORAI1 Calcium Channel Inhibition Reduces Pancreatitis-associated Acute Lung Injury.2
385262082024Insights into the dynamics of the Ca2+ release-activated Ca2+ channel pore-forming complex Orai1.0
389189432024Association of HLA class II gene polymorphisms and expression levels of ORAI1/STIM1 genes in HIV-1‒positive patients with HIV-related dermatoses in Latvia.0
380200662024Neutrophil-specific ORAI1 Calcium Channel Inhibition Reduces Pancreatitis-associated Acute Lung Injury.2
385262082024Insights into the dynamics of the Ca2+ release-activated Ca2+ channel pore-forming complex Orai1.0
389189432024Association of HLA class II gene polymorphisms and expression levels of ORAI1/STIM1 genes in HIV-1‒positive patients with HIV-related dermatoses in Latvia.0
359618372023Super resolution microscopy analysis reveals increased Orai1 activity in asthma and cystic fibrosis lungs.0
365244412023STIM1 and ORAI1 form a novel cold transduction mechanism in sensory and sympathetic neurons.4
366237312023The store-operated Ca(2+) channel Orai1α is required for agonist-evoked NF-κB activation by a mechanism dependent on PKCβ2.2
368063302023A pathogenic human Orai1 mutation unmasks STIM1-independent rapid inactivation of Orai1 channels.2
372277822023Orai1 calcium channel inhibition prevents progression of chronic pancreatitis.3
373322642023Functional differences in agonist-induced plasma membrane expression of Orai1α and Orai1β.0
377591642023Physiological functions of calcium signaling via Orai1 in cancer.3
382794262023Association of Orai1 and Peizo1 genes expression with cellular proliferation, metastasis and angiogenesis biomarkers in colon tumor biopsies of CRC patients.0
359618372023Super resolution microscopy analysis reveals increased Orai1 activity in asthma and cystic fibrosis lungs.0

Citation

Dessen P

ORAI1 (ORAI calcium release-activated calcium modulator 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46187/orai1