Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4998
MIM: 601902
HGNC: 8487
Ensembl: ENSG00000085840
Variants:
dbSNP: 4998
ClinVar: 4998
TCGA: ENSG00000085840
COSMIC: ORC1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000085840 | ENST00000371566 | Q13415 |
| ENSG00000085840 | ENST00000371568 | Q13415 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37772772 | 2024 | Direct regulation of FNIP1 and FNIP2 by MEF2 sustains MTORC1 activation and tumor progression in pancreatic cancer. | 0 |
| 37772772 | 2024 | Direct regulation of FNIP1 and FNIP2 by MEF2 sustains MTORC1 activation and tumor progression in pancreatic cancer. | 0 |
| 37833711 | 2023 | Origin recognition complex subunit 1(ORC1) is a potential biomarker and therapeutic target in cancer. | 0 |
| 37833711 | 2023 | Origin recognition complex subunit 1(ORC1) is a potential biomarker and therapeutic target in cancer. | 0 |
| 36700467 | 2022 | Origin recognition complex subunit 1 (ORC1) augments malignant behaviors of lung adenocarcinoma cells via targeting Wnt signaling. | 4 |
| 36700467 | 2022 | Origin recognition complex subunit 1 (ORC1) augments malignant behaviors of lung adenocarcinoma cells via targeting Wnt signaling. | 4 |
| 33761311 | 2021 | Multiple, short protein binding motifs in ORC1 and CDC6 control the initiation of DNA replication. | 24 |
| 33761311 | 2021 | Multiple, short protein binding motifs in ORC1 and CDC6 control the initiation of DNA replication. | 24 |
| 31866342 | 2020 | Origin recognition complex subunit 1 regulates cell growth and metastasis in glioma by altering activation of ERK and JNK signaling pathway. | 9 |
| 31866342 | 2020 | Origin recognition complex subunit 1 regulates cell growth and metastasis in glioma by altering activation of ERK and JNK signaling pathway. | 9 |
| 31309634 | 2019 | Structural basis for the ORC1-Cyclin A association. | 2 |
| 31309634 | 2019 | Structural basis for the ORC1-Cyclin A association. | 2 |
| 27458800 | 2016 | Opposing roles for DNA replication initiator proteins ORC1 and CDC6 in control of Cyclin E gene transcription. | 19 |
| 27906128 | 2016 | Two subunits of human ORC are dispensable for DNA replication and proliferation. | 25 |
| 27458800 | 2016 | Opposing roles for DNA replication initiator proteins ORC1 and CDC6 in control of Cyclin E gene transcription. | 19 |
Citation
Dessen P
ORC1 (origin recognition complex subunit 1)
Atlas Genet Cytogenet Oncol Haematol. 2011-04-01
Online version: http://atlasgeneticsoncology.org/gene/52158/orc1
