ORC2 (origin recognition complex subunit 2)

2006-10-01  

Identity

HGNC
LOCATION
2q33.1
LOCUSID
ALIAS
ORC2L
FUSION GENES

Other Information

Locus ID:

NCBI: 4999
MIM: 601182
HGNC: 8488
Ensembl: ENSG00000115942

Variants:

dbSNP: 4999
ClinVar: 4999
TCGA: ENSG00000115942
COSMIC: ORC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115942ENST00000234296Q13416
ENSG00000115942ENST00000234296A0A024R411
ENSG00000115942ENST00000410039B8ZZ80
ENSG00000115942ENST00000457595C9JK08

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Cell cycleKEGGhsa04110
Origin recognition complexKEGGhsa_M00284
Origin recognition complexKEGGM00284
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
Activation of ATR in response to replication stressREACTOMER-HSA-176187
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1/S TransitionREACTOMER-HSA-69206
Activation of the pre-replicative complexREACTOMER-HSA-68962
E2F mediated regulation of DNA replicationREACTOMER-HSA-113510
E2F-enabled inhibition of pre-replication complex formationREACTOMER-HSA-113507
S PhaseREACTOMER-HSA-69242
Synthesis of DNAREACTOMER-HSA-69239
Switching of origins to a post-replicative stateREACTOMER-HSA-69052
Orc1 removal from chromatinREACTOMER-HSA-68949
Regulation of DNA replicationREACTOMER-HSA-69304
Association of licensing factors with the pre-replicative complexREACTOMER-HSA-69298
Removal of licensing factors from originsREACTOMER-HSA-69300
M/G1 TransitionREACTOMER-HSA-68874
DNA Replication Pre-InitiationREACTOMER-HSA-69002
Assembly of the pre-replicative complexREACTOMER-HSA-68867
Assembly of the ORC complex at the origin of replicationREACTOMER-HSA-68616
CDC6 association with the ORC:origin complexREACTOMER-HSA-68689
CDT1 association with the CDC6:ORC:origin complexREACTOMER-HSA-68827
DNA ReplicationREACTOMER-HSA-69306

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
128970552003Sequence-independent DNA binding and replication initiation by the human origin recognition complex.131
129129262003Localization of proteins bound to a replication origin of human DNA along the cell cycle.38
219472792011Plk1 phosphorylation of Orc2 promotes DNA replication under conditions of stress.35
117798702002Nuclear organization of DNA replication initiation proteins in mammalian cells.34
231886302013Plk1 phosphorylation of orc2 and hbo1 contributes to gemcitabine resistance in pancreatic cancer.27
164072512006Proliferating human cells hypomorphic for origin recognition complex 2 and pre-replicative complex formation have a defect in p53 activation and Cdk2 kinase activation.18
223346592012Phosphorylation of ORC2 protein dissociates origin recognition complex from chromatin and replication origins.18
159100032005Ku80 binds to human replication origins prior to the assembly of the ORC complex.16
270521772016SUMOylated ORC2 Recruits a Histone Demethylase to Regulate Centromeric Histone Modification and Genomic Stability.12
229357132012Orc2 protects ORCA from ubiquitin-mediated degradation.11

Citation

Dessen P

ORC2 (origin recognition complex subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43387/orc2