ORC5 (origin recognition complex subunit 5)

2006-10-01  

Identity

HGNC
LOCATION
7q22.1
LOCUSID
ALIAS
ORC5L,ORC5P,ORC5T,PPP1R117
FUSION GENES

Other Information

Locus ID:

NCBI: 5001
MIM: 602331
HGNC: 8491
Ensembl: ENSG00000164815

Variants:

dbSNP: 5001
ClinVar: 5001
TCGA: ENSG00000164815
COSMIC: ORC5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164815ENST00000297431O43913
ENSG00000164815ENST00000297431A4D0P7
ENSG00000164815ENST00000422497G3V0H0
ENSG00000164815ENST00000447452O43913
ENSG00000164815ENST00000448563G3V0H0
ENSG00000164815ENST00000626700G3V0H0

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Cell cycleKEGGhsa04110
Origin recognition complexKEGGhsa_M00284
Origin recognition complexKEGGM00284
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
Activation of ATR in response to replication stressREACTOMER-HSA-176187
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1/S TransitionREACTOMER-HSA-69206
Activation of the pre-replicative complexREACTOMER-HSA-68962
E2F mediated regulation of DNA replicationREACTOMER-HSA-113510
E2F-enabled inhibition of pre-replication complex formationREACTOMER-HSA-113507
S PhaseREACTOMER-HSA-69242
Synthesis of DNAREACTOMER-HSA-69239
Switching of origins to a post-replicative stateREACTOMER-HSA-69052
Orc1 removal from chromatinREACTOMER-HSA-68949
Regulation of DNA replicationREACTOMER-HSA-69304
Association of licensing factors with the pre-replicative complexREACTOMER-HSA-69298
Removal of licensing factors from originsREACTOMER-HSA-69300
M/G1 TransitionREACTOMER-HSA-68874
DNA Replication Pre-InitiationREACTOMER-HSA-69002
Assembly of the pre-replicative complexREACTOMER-HSA-68867
Assembly of the ORC complex at the origin of replicationREACTOMER-HSA-68616
CDC6 association with the ORC:origin complexREACTOMER-HSA-68689
CDT1 association with the CDC6:ORC:origin complexREACTOMER-HSA-68827
DNA ReplicationREACTOMER-HSA-69306

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
329890492020A human cancer cell line initiates DNA replication normally in the absence of ORC5 and ORC2 proteins.15
329890492020A human cancer cell line initiates DNA replication normally in the absence of ORC5 and ORC2 proteins.15
266441792016Orc5 induces large-scale chromatin decondensation in a GCN5-dependent manner.10
266441792016Orc5 induces large-scale chromatin decondensation in a GCN5-dependent manner.10
206770142010An approach based on a genome-wide association study reveals candidate loci for narcolepsy.19
206770142010An approach based on a genome-wide association study reveals candidate loci for narcolepsy.19
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.94
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.94

Citation

Dessen P

ORC5 (origin recognition complex subunit 5)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43389/orc5