ORC5 (origin recognition complex subunit 5)

2006-10-01  

Identity

HGNC
LOCATION
7q22.1
LOCUSID
ALIAS
ORC5L,ORC5P,ORC5T,PPP1R117
FUSION GENES

Other Information

Locus ID:

NCBI: 5001
MIM: 602331
HGNC: 8491
Ensembl: ENSG00000164815

Variants:

dbSNP: 5001
ClinVar: 5001
TCGA: ENSG00000164815
COSMIC: ORC5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164815ENST00000297431O43913
ENSG00000164815ENST00000297431A4D0P7
ENSG00000164815ENST00000422497G3V0H0
ENSG00000164815ENST00000447452O43913
ENSG00000164815ENST00000448563G3V0H0
ENSG00000164815ENST00000626700G3V0H0

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Cell cycleKEGGhsa04110
Origin recognition complexKEGGhsa_M00284
Origin recognition complexKEGGM00284
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
Activation of ATR in response to replication stressREACTOMER-HSA-176187
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1/S TransitionREACTOMER-HSA-69206
Activation of the pre-replicative complexREACTOMER-HSA-68962
E2F mediated regulation of DNA replicationREACTOMER-HSA-113510
E2F-enabled inhibition of pre-replication complex formationREACTOMER-HSA-113507
S PhaseREACTOMER-HSA-69242
Synthesis of DNAREACTOMER-HSA-69239
Switching of origins to a post-replicative stateREACTOMER-HSA-69052
Orc1 removal from chromatinREACTOMER-HSA-68949
Regulation of DNA replicationREACTOMER-HSA-69304
Association of licensing factors with the pre-replicative complexREACTOMER-HSA-69298
Removal of licensing factors from originsREACTOMER-HSA-69300
M/G1 TransitionREACTOMER-HSA-68874
DNA Replication Pre-InitiationREACTOMER-HSA-69002
Assembly of the pre-replicative complexREACTOMER-HSA-68867
Assembly of the ORC complex at the origin of replicationREACTOMER-HSA-68616
CDC6 association with the ORC:origin complexREACTOMER-HSA-68689
CDT1 association with the CDC6:ORC:origin complexREACTOMER-HSA-68827
DNA ReplicationREACTOMER-HSA-69306

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
206770142010An approach based on a genome-wide association study reveals candidate loci for narcolepsy.16
266441792016Orc5 induces large-scale chromatin decondensation in a GCN5-dependent manner.2

Citation

Dessen P

ORC5 (origin recognition complex subunit 5)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43389/orc5