ORM2 (orosomucoid 2)

2008-03-01  

Identity

HGNC
LOCATION
9q32
LOCUSID
ALIAS
AGP-B,AGP-B,AGP2

Other Information

Locus ID:

NCBI: 5005
MIM: 138610
HGNC: 8499
Ensembl: ENSG00000228278

Variants:

dbSNP: 5005
ClinVar: 5005
TCGA: ENSG00000228278
COSMIC: ORM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000228278ENST00000431067P19652

Expression (GTEx)

0
500
1000
1500
2000
2500
3000
3500
4000

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA445425Prostatic NeoplasmsDiseaseClinicalAnnotationassociatedPK24619498
PA449383docetaxelChemicalClinicalAnnotationassociatedPK24619498
PA451906warfarinChemicalVariantAnnotationnot associated19794411

References

Pubmed IDYearTitleCitations
361988342023Diagnostic role of plasma ORM2 in differentiating prostate cancer from benign prostatic hyperplasia.1
361988342023Diagnostic role of plasma ORM2 in differentiating prostate cancer from benign prostatic hyperplasia.1
365011942022Influence of Intrauterine Inflammation, Delivery, and Postnatal Feeding on the Temporal Changes of Serum Alpha 1 Acid Glycoprotein Levels in Extremely-Low-Birth-Weight Infants.0
365011942022Influence of Intrauterine Inflammation, Delivery, and Postnatal Feeding on the Temporal Changes of Serum Alpha 1 Acid Glycoprotein Levels in Extremely-Low-Birth-Weight Infants.0
349637382021Orosomucoid in liver diseases.6
349637382021Orosomucoid in liver diseases.6
285542612018Plasma alpha-1-acid glycoprotein as a potential predictive biomarker for non-haematological adverse events of docetaxel in breast cancer patients.3
306009532018Urinary Orosomucoid - 2 and Soluble CD14 as Potential Biomarkers for Assessment of Disease Activity in Rheumatoid Arthritis.3
285542612018Plasma alpha-1-acid glycoprotein as a potential predictive biomarker for non-haematological adverse events of docetaxel in breast cancer patients.3
306009532018Urinary Orosomucoid - 2 and Soluble CD14 as Potential Biomarkers for Assessment of Disease Activity in Rheumatoid Arthritis.3
281936962017Astrocytic Orosomucoid-2 Modulates Microglial Activation and Neuroinflammation.74
286216082017Glycosylation change of alpha-1-acid glycoprotein as a serum biomarker for hepatocellular carcinoma and cirrhosis.17
281936962017Astrocytic Orosomucoid-2 Modulates Microglial Activation and Neuroinflammation.74
286216082017Glycosylation change of alpha-1-acid glycoprotein as a serum biomarker for hepatocellular carcinoma and cirrhosis.17
243590352015Differential interactions and structural stability of chitosan oligomers with human serum albumin and α-1-glycoprotein.2

Citation

Dessen P

ORM2 (orosomucoid 2)

Atlas Genet Cytogenet Oncol Haematol. 2008-03-01

Online version: http://atlasgeneticsoncology.org/gene/50042/orm2