OSBPL3 (oxysterol binding protein like 3)

2014-11-01  

Identity

HGNC
LOCATION
7p15.3
LOCUSID
ALIAS
ORP-3,ORP3,OSBP3
FUSION GENES

Other Information

Locus ID:

NCBI: 26031
MIM: 606732
HGNC: 16370
Ensembl: ENSG00000070882

Variants:

dbSNP: 26031
ClinVar: 26031
TCGA: ENSG00000070882
COSMIC: OSBPL3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000070882ENST00000313367Q9H4L5
ENSG00000070882ENST00000396429Q9H4L5
ENSG00000070882ENST00000396431Q9H4L5
ENSG00000070882ENST00000409069Q9H4L5
ENSG00000070882ENST00000409452Q9H4L5
ENSG00000070882ENST00000409555Q9H4L5
ENSG00000070882ENST00000409759Q9H4L5
ENSG00000070882ENST00000409863Q9H4L5
ENSG00000070882ENST00000415162C9JZ19
ENSG00000070882ENST00000415952C9J8P4
ENSG00000070882ENST00000441059C9JEF2

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Bile acid and bile salt metabolismREACTOMER-HSA-194068
Synthesis of bile acids and bile saltsREACTOMER-HSA-192105

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
182702672008The R-Ras interaction partner ORP3 regulates cell adhesion.23
254472042015OSBP-related protein 3 (ORP3) coupling with VAMP-associated protein A regulates R-Ras activity.20
161433242005Targeting of OSBP-related protein 3 (ORP3) to endoplasmic reticulum and plasma membrane is controlled by multiple determinants.17
300181352018VAMP-associated protein-A and oxysterol-binding protein-related protein 3 promote the entry of late endosomes into the nucleoplasmic reticulum.7
268124962016Oxysterol-binding protein ORP3 rescues the Amyotrophic Lateral Sclerosis-linked mutant VAPB phenotype.3

Citation

Dessen P

OSBPL3 (oxysterol binding protein like 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71553/osbpl3