OTUB1 (OTU deubiquitinase, ubiquitin aldehyde binding 1)

2004-04-01  

Identity

HGNC
OTUB1
LOCATION
11q13.1
LOCUSID
55611
ALIAS
HSPC263,OTB1,OTU1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55611
MIM: 608337
HGNC: 23077
Ensembl: ENSG00000167770

Variants:

dbSNP: 55611
ClinVar: 55611
TCGA: ENSG00000167770
COSMIC: OTUB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167770ENST00000422031J3KR44
ENSG00000167770ENST00000428192Q96FW1
ENSG00000167770ENST00000535140F5H4F3
ENSG00000167770ENST00000535715F5GYJ8
ENSG00000167770ENST00000538426Q96FW1
ENSG00000167770ENST00000541478F5H3F0
ENSG00000167770ENST00000543004F5H6Q1
ENSG00000167770ENST00000543988F5GYN4

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880
Ovarian tumor domain proteasesREACTOMER-HSA-5689896

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
207250332010Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1.138
223675392012The mechanism of OTUB1-mediated inhibition of ubiquitination.85
189543052009Structural basis and specificity of human otubain 1-mediated deubiquitination.84
223253552012OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function.73
221243272012Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1.72
199960942010Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6.71
192110262009Evidence for bidentate substrate binding as the basis for the K48 linkage specificity of otubain 1.65
239550222013E2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of OTUB1.47
240717382013OTUB1 enhances TGFβ signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3.43
235248492013OTUB1 modulates c-IAP1 stability to regulate signalling pathways.39

Citation

Dessen P

OTUB1 (OTU deubiquitinase, ubiquitin aldehyde binding 1)

Atlas Genet Cytogenet Oncol Haematol. 2004-04-01

Online version: http://atlasgeneticsoncology.org/gene/41619/otub1