OTUB2 (OTU deubiquitinase, ubiquitin aldehyde binding 2)

2004-04-01  

Identity

HGNC
OTUB2
LOCATION
14q32.12
LOCUSID
78990
ALIAS
C14orf137,OTB2,OTU2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 78990
MIM: 608338
HGNC: 20351
Ensembl: ENSG00000089723

Variants:

dbSNP: 78990
ClinVar: 78990
TCGA: ENSG00000089723
COSMIC: OTUB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000089723ENST00000203664Q96DC9
ENSG00000089723ENST00000553723Q96DC9

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ovarian tumor domain proteasesREACTOMER-HSA-5689896

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
appendix
spleen
lymph node
tonsil

References

Pubmed IDYearTitleCitations
199960942010Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6.71
245602722014Fine-tuning of DNA damage-dependent ubiquitination by OTUB2 supports the DNA repair pathway choice.39
152586132004Crystal structure of human otubain 2.29
235156852013Otubain 2 is a novel promoter of beta cell survival as revealed by siRNA high-throughput screens of human pancreatic islets.8
304721882019OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ.7
306625612019OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer.7
302419372018Regulation of Gli2 stability by deubiquitinase OTUB2.2

Citation

Dessen P

OTUB2 (OTU deubiquitinase, ubiquitin aldehyde binding 2)

Atlas Genet Cytogenet Oncol Haematol. 2004-04-01

Online version: http://atlasgeneticsoncology.org/gene/865/otub2