Identity
HGNC
LOCATION
14q32.12
LOCUSID
ALIAS
C14orf137,OTB2,OTU2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 78990
MIM: 608338
HGNC: 20351
Ensembl: ENSG00000089723
Variants:
dbSNP: 78990
ClinVar: 78990
TCGA: ENSG00000089723
COSMIC: OTUB2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000089723 | ENST00000203664 | Q96DC9 |
| ENSG00000089723 | ENST00000553723 | Q96DC9 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38167274 | 2024 | Pharmaceutical targeting of OTUB2 sensitizes tumors to cytotoxic T cells via degradation of PD-L1. | 1 |
| 38702967 | 2024 | Exploring the regulatory role of FBXL19-AS1 in triple-negative breast cancer through the miR-378a-3p/OTUB2 axis. | 0 |
| 38167274 | 2024 | Pharmaceutical targeting of OTUB2 sensitizes tumors to cytotoxic T cells via degradation of PD-L1. | 1 |
| 38702967 | 2024 | Exploring the regulatory role of FBXL19-AS1 in triple-negative breast cancer through the miR-378a-3p/OTUB2 axis. | 0 |
| 36316812 | 2023 | OTUB2 promotes the progression of endometrial cancer by regulating the PKM2-mediated PI3K/AKT signaling pathway. | 2 |
| 36858343 | 2023 | Deubiquitinase OTUB2 promotes intrahepatic cholangiocarcinoma progression by stabilizing the CTNNB1-ZEB1 axis. | 1 |
| 37169754 | 2023 | Molecular basis for recognition and deubiquitination of 40S ribosomes by Otu2. | 4 |
| 37334762 | 2023 | RBM15 m(6) A modification-mediated OTUB2 upregulation promotes cervical cancer progression via the AKT/mTOR signaling. | 2 |
| 36316812 | 2023 | OTUB2 promotes the progression of endometrial cancer by regulating the PKM2-mediated PI3K/AKT signaling pathway. | 2 |
| 36858343 | 2023 | Deubiquitinase OTUB2 promotes intrahepatic cholangiocarcinoma progression by stabilizing the CTNNB1-ZEB1 axis. | 1 |
| 37169754 | 2023 | Molecular basis for recognition and deubiquitination of 40S ribosomes by Otu2. | 4 |
| 37334762 | 2023 | RBM15 m(6) A modification-mediated OTUB2 upregulation promotes cervical cancer progression via the AKT/mTOR signaling. | 2 |
| 32003539 | 2020 | Knockdown of otubain 2 inhibits liver cancer cell growth by suppressing NF-κB signaling. | 7 |
| 32265297 | 2020 | Activation and selectivity of OTUB-1 and OTUB-2 deubiquitinylases. | 10 |
| 32830515 | 2020 | OTUB2 Promotes Homologous Recombination Repair Through Stimulating Rad51 Expression in Endometrial Cancer. | 4 |
Citation
Dessen P
OTUB2 (OTU deubiquitinase, ubiquitin aldehyde binding 2)
Atlas Genet Cytogenet Oncol Haematol. 2004-04-01
Online version: http://atlasgeneticsoncology.org/gene/865/otub2
