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OTUD6B (OTU deubiquitinase 6B)

Identity

Alias_namesOTU domain containing 6B
Alias_symbol (synonym)CGI-77
DUBA5
Other aliasDUBA-5
IDDFSDA
HGNC (Hugo) OTUD6B
LocusID (NCBI) 51633
Atlas_Id 56448
Location 8q21.3  [Link to chromosome band 8q21]
Location_base_pair Starts at 91070344 and ends at 91087093 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
OTUD6B (8q21.3) / LRRC69 (8q21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)OTUD6B   24281
Cards
Entrez_Gene (NCBI)OTUD6B  51633  OTU deubiquitinase 6B
AliasesCGI-77; DUBA-5; DUBA5; IDDFSDA
GeneCards (Weizmann)OTUD6B
Ensembl hg19 (Hinxton)ENSG00000155100 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000155100 [Gene_View]  ENSG00000155100 [Sequence]  chr8:91070344-91087093 [Contig_View]  OTUD6B [Vega]
ICGC DataPortalENSG00000155100
TCGA cBioPortalOTUD6B
AceView (NCBI)OTUD6B
Genatlas (Paris)OTUD6B
WikiGenes51633
SOURCE (Princeton)OTUD6B
Genetics Home Reference (NIH)OTUD6B
Genomic and cartography
GoldenPath hg38 (UCSC)OTUD6B  -     chr8:91070344-91087093 +  8q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)OTUD6B  -     8q21.3   [Description]    (hg19-Feb_2009)
GoldenPathOTUD6B - 8q21.3 [CytoView hg19]  OTUD6B - 8q21.3 [CytoView hg38]
ImmunoBaseENSG00000155100
Mapping of homologs : NCBIOTUD6B [Mapview hg19]  OTUD6B [Mapview hg38]
OMIM612021   617452   
Gene and transcription
Genbank (Entrez)AA748163 AF151836 AK291646 AK293843 AK310823
RefSeq transcript (Entrez)NM_001286745 NM_016023
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)OTUD6B
Alternative Splicing GalleryENSG00000155100
Gene ExpressionOTUD6B [ NCBI-GEO ]   OTUD6B [ EBI - ARRAY_EXPRESS ]   OTUD6B [ SEEK ]   OTUD6B [ MEM ]
Gene Expression Viewer (FireBrowse)OTUD6B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51633
GTEX Portal (Tissue expression)OTUD6B
Human Protein AtlasENSG00000155100-OTUD6B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N6M0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N6M0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N6M0
Splice isoforms : SwissVarQ8N6M0
PhosPhoSitePlusQ8N6M0
Domaine pattern : Prosite (Expaxy)OTU (PS50802)   
Domains : Interpro (EBI)OTU_dom    Papain-like_cys_pep_sf   
Domain families : Pfam (Sanger)OTU (PF02338)   
Domain families : Pfam (NCBI)pfam02338   
Conserved Domain (NCBI)OTUD6B
DMDM Disease mutations51633
Blocks (Seattle)OTUD6B
SuperfamilyQ8N6M0
Human Protein Atlas [tissue]ENSG00000155100-OTUD6B [tissue]
Peptide AtlasQ8N6M0
HPRD13041
IPIIPI00935722   IPI00182180   IPI00977951   
Protein Interaction databases
DIP (DOE-UCLA)Q8N6M0
IntAct (EBI)Q8N6M0
FunCoupENSG00000155100
BioGRIDOTUD6B
STRING (EMBL)OTUD6B
ZODIACOTUD6B
Ontologies - Pathways
QuickGOQ8N6M0
Ontology : AmiGOthiol-dependent ubiquitin-specific protease activity  cell proliferation  eukaryotic translation initiation factor 4F complex  protein deubiquitination  protein deubiquitination  protein deubiquitination  thiol-dependent ubiquitinyl hydrolase activity  proteasome assembly  
Ontology : EGO-EBIthiol-dependent ubiquitin-specific protease activity  cell proliferation  eukaryotic translation initiation factor 4F complex  protein deubiquitination  protein deubiquitination  protein deubiquitination  thiol-dependent ubiquitinyl hydrolase activity  proteasome assembly  
NDEx NetworkOTUD6B
Atlas of Cancer Signalling NetworkOTUD6B
Wikipedia pathwaysOTUD6B
Orthology - Evolution
OrthoDB51633
GeneTree (enSembl)ENSG00000155100
Phylogenetic Trees/Animal Genes : TreeFamOTUD6B
HOGENOMQ8N6M0
Homologs : HomoloGeneOTUD6B
Homology/Alignments : Family Browser (UCSC)OTUD6B
Gene fusions - Rearrangements
Fusion : QuiverOTUD6B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOTUD6B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OTUD6B
dbVarOTUD6B
ClinVarOTUD6B
1000_GenomesOTUD6B 
Exome Variant ServerOTUD6B
ExAC (Exome Aggregation Consortium)ENSG00000155100
GNOMAD BrowserENSG00000155100
Varsome BrowserOTUD6B
Genetic variants : HAPMAP51633
Genomic Variants (DGV)OTUD6B [DGVbeta]
DECIPHEROTUD6B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisOTUD6B 
Mutations
ICGC Data PortalOTUD6B 
TCGA Data PortalOTUD6B 
Broad Tumor PortalOTUD6B
OASIS PortalOTUD6B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOTUD6B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DOTUD6B
Mutations and Diseases : HGMDOTUD6B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch OTUD6B
DgiDB (Drug Gene Interaction Database)OTUD6B
DoCM (Curated mutations)OTUD6B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)OTUD6B (select a term)
intoGenOTUD6B
Cancer3DOTUD6B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612021    617452   
Orphanet
DisGeNETOTUD6B
MedgenOTUD6B
Genetic Testing Registry OTUD6B
NextProtQ8N6M0 [Medical]
TSGene51633
GENETestsOTUD6B
Target ValidationOTUD6B
Huge Navigator OTUD6B [HugePedia]
snp3D : Map Gene to Disease51633
BioCentury BCIQOTUD6B
ClinGenOTUD6B
Clinical trials, drugs, therapy
Protein Interactions : CTD51633
Pharm GKB GenePA142671219
Clinical trialOTUD6B
Miscellaneous
canSAR (ICR)OTUD6B (select the gene name)
HarmonizomeOTUD6B
DataMed IndexOTUD6B
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineOTUD6B
EVEXOTUD6B
GoPubMedOTUD6B
iHOPOTUD6B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Jun 30 20:26:01 CEST 2020
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