OTUD7B (OTU deubiquitinase 7B)

2003-12-01  

Identity

HGNC
OTUD7B
LOCATION
1q21.2
LOCUSID
56957
ALIAS
CEZANNE,ZA20D1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 56957
MIM: 611748
HGNC: 16683
Ensembl: ENSG00000264522

Variants:

dbSNP: 56957
ClinVar: 56957
TCGA: ENSG00000264522
COSMIC: OTUD7B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000264522ENST00000417191Q5SZ59
ENSG00000264522ENST00000581312Q6GQQ9

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Signal TransductionREACTOMER-HSA-162582
Death Receptor SignallingREACTOMER-HSA-73887
TNF signalingREACTOMER-HSA-75893
TNFR1-induced proapoptotic signalingREACTOMER-HSA-5357786
TNFR1-induced NFkappaB signaling pathwayREACTOMER-HSA-5357956
Regulation of TNFR1 signalingREACTOMER-HSA-5357905
DeubiquitinationREACTOMER-HSA-5688426
Ovarian tumor domain proteasesREACTOMER-HSA-5689896

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
206228742010Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne.125
181785512008NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling.76
126820622003A novel type of deubiquitinating enzyme.50
277325842016Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.35
284898222017TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling.33
221798312012Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression.29
253550432014Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner.26
210975102011DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB.21
235646402013Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination.21
261485122015Cezanne regulates E2F1-dependent HIF2α expression.19

Citation

Dessen P

OTUD7B (OTU deubiquitinase 7B)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/42862/otud7b