Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5013
MIM: 600036
HGNC: 8521
Ensembl: ENSG00000115507
Variants:
dbSNP: 5013
ClinVar: 5013
TCGA: ENSG00000115507
COSMIC: OTX1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000115507 | ENST00000282549 | P32242 |
| ENSG00000115507 | ENST00000366671 | P32242 |
| ENSG00000115507 | ENST00000405984 | B5MC54 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Signaling pathways regulating pluripotency of stem cells | KEGG | hsa04550 |
| Signaling pathways regulating pluripotency of stem cells | KEGG | ko04550 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38218040 | 2024 | OTX1 regulates tumorigenesis and metastasis in glioma. | 0 |
| 38218040 | 2024 | OTX1 regulates tumorigenesis and metastasis in glioma. | 0 |
| 36093844 | 2023 | MiR-195-5p suppresses gastric adenocarcinoma cell progression via targeting OTX1. | 0 |
| 36093844 | 2023 | MiR-195-5p suppresses gastric adenocarcinoma cell progression via targeting OTX1. | 0 |
| 35303522 | 2022 | Overexpression of OTX1 promotes tumorigenesis in patients with esophageal squamous cell carcinoma. | 3 |
| 35474406 | 2022 | Knockdown of circMYOF inhibits cell growth, metastasis, and glycolysis through miR-145-5p/OTX1 regulatory axis in laryngeal squamous cell carcinoma. | 3 |
| 36177903 | 2022 | OTX1 promotes tumorigenesis and progression of cervical cancer by regulating the Wnt signaling pathway. | 2 |
| 35303522 | 2022 | Overexpression of OTX1 promotes tumorigenesis in patients with esophageal squamous cell carcinoma. | 3 |
| 35474406 | 2022 | Knockdown of circMYOF inhibits cell growth, metastasis, and glycolysis through miR-145-5p/OTX1 regulatory axis in laryngeal squamous cell carcinoma. | 3 |
| 36177903 | 2022 | OTX1 promotes tumorigenesis and progression of cervical cancer by regulating the Wnt signaling pathway. | 2 |
| 34559577 | 2021 | Orthodenticle homeobox OTX1 is a potential prognostic biomarker for bladder cancer. | 9 |
| 34559577 | 2021 | Orthodenticle homeobox OTX1 is a potential prognostic biomarker for bladder cancer. | 9 |
| 32325080 | 2020 | Long non-coding RNA HNF1A-AS1 upregulates OTX1 to enhance angiogenesis in colon cancer via the binding of transcription factor PBX3. | 14 |
| 32419651 | 2020 | miR-3196 acts as a Tumor Suppressor and Predicts Survival Outcomes in Patients With Gastric Cancer. | 3 |
| 32549762 | 2020 | MicroRNA-4516 suppresses pancreatic cancer development via negatively regulating orthodenticle homeobox 1. | 11 |
Citation
Dessen P
OTX1 (orthodenticle homeobox 1)
Atlas Genet Cytogenet Oncol Haematol. 2010-03-01
Online version: http://atlasgeneticsoncology.org/gene/51362/otx1
