Atlas of Genetics and Cytogenetics in Oncology and Haematology

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OXR1 (oxidation resistance 1)

Identity

Alias_symbol (synonym)TLDC3
Other aliasNbla00307
HGNC (Hugo) OXR1
LocusID (NCBI) 55074
Atlas_Id 54522
Location 8q23.1  [Link to chromosome band 8q23]
Location_base_pair Starts at 106657808 and ends at 106752693 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATP6V0E1 (5q35.1) / OXR1 (8q23.1)C3 (19p13.3) / OXR1 (8q23.1)IREB2 (15q25.1) / OXR1 (8q23.1)
KDM5B (1q32.1) / OXR1 (8q23.1)MALAT1 (11q13.1) / OXR1 (8q23.1)OXR1 (8q23.1) / CAV1 (7q31.2)
OXR1 (8q23.1) / COX6C (8q22.2)OXR1 (8q23.1) / CSMD3 (8q23.3)OXR1 (8q23.1) / LRCH4 (7q22.1)
OXR1 (8q23.1) / MET (7q31.2)OXR1 (8q23.1) / OXR1 (8q23.1)OXR1 (8q23.1) / RSPO2 (8q23.1)
PTPRK (6q22.33) / OXR1 (8q23.1)RSPO2 (8q23.1) / OXR1 (8q23.1)STK3 (8q22.2) / OXR1 (8q23.1)
YWHAZ (8q22.3) / OXR1 (8q23.1)ZNF559 (19p13.2) / OXR1 (8q23.1)OXR1 8q23.1 / CSMD3 8q23.3
PTPRK 6q22.33 / OXR1 8q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 9 ]
  Lung: Translocations in Small Cell Carcinoma
Lung: Translocations in Squamous Cell Carcinoma
inv(8)(q22q23) OXR1/COX6C
inv(8)(q22q23) YWHAZ/OXR1
t(6;8)(q22;q23) PTPRK/OXR1
t(7;8)(q31;q23) OXR1/MET
OXR1/CSMD3 (8q23)
RSPO2/OXR1 (8q23)
OXR1/RSPO2 (8q23)

External links

Nomenclature
HGNC (Hugo)OXR1   15822
Cards
Entrez_Gene (NCBI)OXR1  55074  oxidation resistance 1
AliasesNbla00307; TLDC3
GeneCards (Weizmann)OXR1
Ensembl hg19 (Hinxton)ENSG00000164830 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164830 [Gene_View]  ENSG00000164830 [Sequence]  chr8:106657808-106752693 [Contig_View]  OXR1 [Vega]
ICGC DataPortalENSG00000164830
TCGA cBioPortalOXR1
AceView (NCBI)OXR1
Genatlas (Paris)OXR1
WikiGenes55074
SOURCE (Princeton)OXR1
Genetics Home Reference (NIH)OXR1
Genomic and cartography
GoldenPath hg38 (UCSC)OXR1  -     chr8:106657808-106752693 +  8q23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)OXR1  -     8q23.1   [Description]    (hg19-Feb_2009)
GoldenPathOXR1 - 8q23.1 [CytoView hg19]  OXR1 - 8q23.1 [CytoView hg38]
ImmunoBaseENSG00000164830
Mapping of homologs : NCBIOXR1 [Mapview hg19]  OXR1 [Mapview hg38]
OMIM605609   
Gene and transcription
Genbank (Entrez)AB075503 AF309387 AK000987 AK096148 AK098168
RefSeq transcript (Entrez)NM_001198532 NM_001198533 NM_001198534 NM_001198535 NM_018002 NM_181354
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)OXR1
Cluster EST : UnigeneHs.701892 [ NCBI ]
CGAP (NCI)Hs.701892
Alternative Splicing GalleryENSG00000164830
Gene ExpressionOXR1 [ NCBI-GEO ]   OXR1 [ EBI - ARRAY_EXPRESS ]   OXR1 [ SEEK ]   OXR1 [ MEM ]
Gene Expression Viewer (FireBrowse)OXR1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55074
GTEX Portal (Tissue expression)OXR1
Human Protein AtlasENSG00000164830-OXR1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N573   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N573  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N573
Splice isoforms : SwissVarQ8N573
PhosPhoSitePlusQ8N573
Domaine pattern : Prosite (Expaxy)LYSM (PS51782)   
Domains : Interpro (EBI)LysM_dom    LysM_dom_sf    TLDc_dom   
Domain families : Pfam (Sanger)LysM (PF01476)    TLD (PF07534)   
Domain families : Pfam (NCBI)pfam01476    pfam07534   
Domain families : Smart (EMBL)LysM (SM00257)  TLDc (SM00584)  
Conserved Domain (NCBI)OXR1
DMDM Disease mutations55074
Blocks (Seattle)OXR1
SuperfamilyQ8N573
Human Protein Atlas [tissue]ENSG00000164830-OXR1 [tissue]
Peptide AtlasQ8N573
HPRD16126
IPIIPI00942506   IPI00298348   IPI00166807   IPI00747160   IPI00956603   IPI00902977   IPI00924486   IPI00927650   IPI00976096   IPI00973351   IPI00976747   IPI00985502   IPI01010227   
Protein Interaction databases
DIP (DOE-UCLA)Q8N573
IntAct (EBI)Q8N573
FunCoupENSG00000164830
BioGRIDOXR1
STRING (EMBL)OXR1
ZODIACOXR1
Ontologies - Pathways
QuickGOQ8N573
Ontology : AmiGOmolecular_function  nucleoplasm  nucleolus  mitochondrion  response to oxidative stress  adult walking behavior  oxidoreductase activity  intracellular membrane-bounded organelle  negative regulation of neuron apoptotic process  neuron apoptotic process  oxidation-reduction process  cellular response to hydroperoxide  negative regulation of peptidyl-cysteine S-nitrosylation  negative regulation of oxidative stress-induced neuron death  
Ontology : EGO-EBImolecular_function  nucleoplasm  nucleolus  mitochondrion  response to oxidative stress  adult walking behavior  oxidoreductase activity  intracellular membrane-bounded organelle  negative regulation of neuron apoptotic process  neuron apoptotic process  oxidation-reduction process  cellular response to hydroperoxide  negative regulation of peptidyl-cysteine S-nitrosylation  negative regulation of oxidative stress-induced neuron death  
NDEx NetworkOXR1
Atlas of Cancer Signalling NetworkOXR1
Wikipedia pathwaysOXR1
Orthology - Evolution
OrthoDB55074
GeneTree (enSembl)ENSG00000164830
Phylogenetic Trees/Animal Genes : TreeFamOXR1
HOGENOMQ8N573
Homologs : HomoloGeneOXR1
Homology/Alignments : Family Browser (UCSC)OXR1
Gene fusions - Rearrangements
Fusion : MitelmanOXR1/COX6C [8q23.1/8q22.2]  
Fusion : MitelmanOXR1/CSMD3 [8q23.1/8q23.3]  [t(8;8)(q23;q23)]  
Fusion : MitelmanOXR1/RSPO2 [8q23.1/8q23.1]  [t(8;8)(q23;q23)]  
Fusion : MitelmanPTPRK/OXR1 [6q22.33/8q23.1]  [t(6;8)(q22;q23)]  
Fusion : MitelmanRSPO2/OXR1 [8q23.1/8q23.1]  [t(8;8)(q23;q23)]  
Fusion : MitelmanYWHAZ/OXR1 [8q22.3/8q23.1]  [inv(8)(q22q23)]  
Fusion PortalOXR1 8q23.1 CSMD3 8q23.3 BRCA
Fusion PortalPTPRK 6q22.33 OXR1 8q23.1 BRCA
Fusion : QuiverOXR1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOXR1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OXR1
dbVarOXR1
ClinVarOXR1
1000_GenomesOXR1 
Exome Variant ServerOXR1
ExAC (Exome Aggregation Consortium)ENSG00000164830
GNOMAD BrowserENSG00000164830
Varsome BrowserOXR1
Genetic variants : HAPMAP55074
Genomic Variants (DGV)OXR1 [DGVbeta]
DECIPHEROXR1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisOXR1 
Mutations
ICGC Data PortalOXR1 
TCGA Data PortalOXR1 
Broad Tumor PortalOXR1
OASIS PortalOXR1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOXR1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DOXR1
Mutations and Diseases : HGMDOXR1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch OXR1
DgiDB (Drug Gene Interaction Database)OXR1
DoCM (Curated mutations)OXR1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)OXR1 (select a term)
intoGenOXR1
Cancer3DOXR1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605609   
Orphanet
DisGeNETOXR1
MedgenOXR1
Genetic Testing Registry OXR1
NextProtQ8N573 [Medical]
TSGene55074
GENETestsOXR1
Target ValidationOXR1
Huge Navigator OXR1 [HugePedia]
snp3D : Map Gene to Disease55074
BioCentury BCIQOXR1
ClinGenOXR1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55074
Chemical/Pharm GKB GenePA32856
Clinical trialOXR1
Miscellaneous
canSAR (ICR)OXR1 (select the gene name)
DataMed IndexOXR1
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineOXR1
EVEXOXR1
GoPubMedOXR1
iHOPOXR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:59:25 CET 2019
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