P2RY1 (purinergic receptor P2Y1)

2007-02-01  

Identity

HGNC
LOCATION
3q25.2
LOCUSID
ALIAS
P2Y1,SARCC

Other Information

Locus ID:

NCBI: 5028
MIM: 601167
HGNC: 8539
Ensembl: ENSG00000169860

Variants:

dbSNP: 5028
ClinVar: 5028
TCGA: ENSG00000169860
COSMIC: P2RY1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169860ENST00000305097P47900

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Taste transductionKEGGko04742
Neuroactive ligand-receptor interactionKEGGhsa04080
Taste transductionKEGGhsa04742
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Platelet activationKEGGhsa04611
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Signal amplificationREACTOMER-HSA-392518
ADP signalling through P2Y purinoceptor 1REACTOMER-HSA-418592
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Nucleotide-like (purinergic) receptorsREACTOMER-HSA-418038
P2Y receptorsREACTOMER-HSA-417957
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA166156291rs701265VariantVipGeneassociated16581111, 15514209
PA166156310rs1065776VariantVipGeneassociated17559347, 15757620
PA174GNAQGenePathwayassociated20938371
PA176GNB3GenePathwayassociated20938371
PA28764GNA11GenePathwayassociated20938371
PA28765GNA12GenePathwayassociated20938371
PA28766GNA13GenePathwayassociated20938371
PA28768GNA15GenePathwayassociated20938371
PA445019Myocardial InfarctionDiseaseClinicalAnnotationassociatedPD15757620, 17559347, 22940005
PA448497aspirinChemicalClinicalAnnotationassociatedPD15757620, 17559347, 22940005

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
258227902015Two disparate ligand-binding sites in the human P2Y1 receptor.82
170957472007A polymorphism in the P2X7 gene increases susceptibility to extrapulmonary tuberculosis.71
156651142005P2Y1 and P2Y12 receptors for ADP desensitize by distinct kinase-dependent mechanisms.49
204733982010P2Y12 or P2Y1 inhibitors reduce platelet deposition in a microfluidic model of thrombosis while apyrase lacks efficacy under flow conditions.48
151870292004Reciprocal cross-talk between P2Y1 and P2Y12 receptors at the level of calcium signaling in human platelets.43
116906422001Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study.41
128804242003Expression of purinergic receptors in non-melanoma skin cancers and their functional roles in A431 cells.35
127871282003Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes.29
200639892010The effect of P2Y-mediated platelet activation on the release of VEGF and endostatin from platelets.29

Citation

Dessen P

P2RY1 (purinergic receptor P2Y1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45562/p2ry1