P2RY2 (purinergic receptor P2Y2)

2003-10-01 Affiliation

Identity

HGNC

P2RY2

LOCATION

11q13.4

LOCUSID

5029

ALIAS

HP2U,P2RU1,P2U,P2U1,P2UR,P2Y2,P2Y2R

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5029
MIM: 600041
HGNC: 8541
Ensembl: ENSG00000175591

Variants:

dbSNP: 5029
ClinVar: 5029
TCGA: ENSG00000175591
COSMIC: P2RY2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000175591	ENST00000311131	P41231
ENSG00000175591	ENST00000393596	P41231
ENSG00000175591	ENST00000393597	P41231

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Inflammatory mediator regulation of TRP channels	KEGG	hsa04750
Inflammatory mediator regulation of TRP channels	KEGG	ko04750
Metabolism of proteins	REACTOME	R-HSA-392499
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Nucleotide-like (purinergic) receptors	REACTOME	R-HSA-418038
P2Y receptors	REACTOME	R-HSA-417957
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (q) signalling events	REACTOME	R-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
Surfactant metabolism	REACTOME	R-HSA-5683826

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
17170310	2006	ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors.	325
23810565	2013	Platelet-derived nucleotides promote tumor-cell transendothelial migration and metastasis via P2Y2 receptor.	145
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
20880147	2010	The purinergic receptor P2Y2 receptor mediates chemotaxis of dendritic cells and eosinophils in allergic lung inflammation.	59
21859844	2011	Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection.	58
15175347	2004	The P2Y2 nucleotide receptor mediates vascular cell adhesion molecule-1 expression through interaction with VEGF receptor-2 (KDR/Flk-1).	56
14670955	2004	Src homology 3 binding sites in the P2Y2 nucleotide receptor interact with Src and regulate activities of Src, proline-rich tyrosine kinase 2, and growth factor receptors.	54
26168216	2015	P2Y₂ and Gq/G₁₁ control blood pressure by mediating endothelial mechanotransduction.	47
19118095	2009	ATP-induced vasodilation and purinergic receptors in the human leg: roles of nitric oxide, prostaglandins, and adenosine.	45
15778502	2005	P2Y2 nucleotide receptors enhance alpha-secretase-dependent amyloid precursor protein processing.	43

Citation

Dessen P

P2RY2 (purinergic receptor P2Y2)

Atlas Genet Cytogenet Oncol Haematol. 2003-10-01

Online version: http://atlasgeneticsoncology.org/gene/41625/p2ry2