P2RY4 (pyrimidinergic receptor P2Y4)

2014-11-01  

Identity

HGNC
LOCATION
Xq13.1
LOCUSID
ALIAS
NRU,P2P,P2Y4,UNR

Other Information

Locus ID:

NCBI: 5030
MIM: 300038
HGNC: 8542
Ensembl: ENSG00000186912

Variants:

dbSNP: 5030
ClinVar: 5030
TCGA: ENSG00000186912
COSMIC: P2RY4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186912ENST00000374519P51582

Expression (GTEx)

0
1
2

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Taste transductionKEGGko04742
Neuroactive ligand-receptor interactionKEGGhsa04080
Taste transductionKEGGhsa04742
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Nucleotide-like (purinergic) receptorsREACTOMER-HSA-418038
P2Y receptorsREACTOMER-HSA-417957
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
116906422001Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study.41
126231232003Tumor necrosis factor alpha-induced apoptosis in astrocytes is prevented by the activation of P2Y6, but not P2Y4 nucleotide receptors.18
126038582003Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors.14
212193312011Proteinase-activated receptors, nucleotide P2Y receptors, and μ-opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking.12
146709662004Agonist versus antagonist action of ATP at the P2Y4 receptor is determined by the second extracellular loop.11
227769022012Trauma-induced expression of astrocytic thrombospondin-1 is regulated by P2 receptors coupled to protein kinase cascades.8
156497002005The metabotropic P2Y4 receptor participates in the commitment to differentiation and cell death of human neuroblastoma SH-SY5Y cells.7
220525572012Purinergic receptors expressed in human skeletal muscle fibres.5
250032382014Expression of astrocyte-related receptors in cortical dysplasia with intractable epilepsy.5

Citation

Dessen P

P2RY4 (pyrimidinergic receptor P2Y4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71608/p2ry4