PABPC1 (poly(A) binding protein cytoplasmic 1)

2007-02-01  

Identity

HGNC
PABPC1
LOCATION
8q22.3
LOCUSID
26986
ALIAS
PAB1,PABP,PABP1,PABPC2,PABPL1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 26986
MIM: 604679
HGNC: 8554
Ensembl: ENSG00000070756

Variants:

dbSNP: 26986
ClinVar: 26986
TCGA: ENSG00000070756
COSMIC: PABPC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000070756ENST00000318607P11940
ENSG00000070756ENST00000318607A0A024R9C1
ENSG00000070756ENST00000517403H0YAW6
ENSG00000070756ENST00000517990H0YAS7
ENSG00000070756ENST00000518196E5RGH3
ENSG00000070756ENST00000518293H0YC10
ENSG00000070756ENST00000519004E7EQV3
ENSG00000070756ENST00000519100H0YAR2
ENSG00000070756ENST00000519363E5RJM8
ENSG00000070756ENST00000519622H0YAP2
ENSG00000070756ENST00000520142E5RH24
ENSG00000070756ENST00000520804E5RGC4
ENSG00000070756ENST00000520868H0YAS6
ENSG00000070756ENST00000521067E5RFD8
ENSG00000070756ENST00000521865E5RJB9
ENSG00000070756ENST00000522387E7ERJ7
ENSG00000070756ENST00000522658H0YB75
ENSG00000070756ENST00000522720E5RHG7
ENSG00000070756ENST00000523555H0YBN4
ENSG00000070756ENST00000523636H0YB86
ENSG00000070756ENST00000610907A0A087WTT1

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
RNA transportKEGGko03013
RNA transportKEGGhsa03013
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation InitiationREACTOMER-HSA-72613
Cap-dependent Translation InitiationREACTOMER-HSA-72737
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43SREACTOMER-HSA-72662
Translation initiation complex formationREACTOMER-HSA-72649
L13a-mediated translational silencing of Ceruloplasmin expressionREACTOMER-HSA-156827
Gene ExpressionREACTOMER-HSA-74160
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
Deadenylation of mRNAREACTOMER-HSA-429947
Nonsense-Mediated Decay (NMD)REACTOMER-HSA-927802
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)REACTOMER-HSA-975957
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)REACTOMER-HSA-975956
Regulation of mRNA stability by proteins that bind AU-rich elementsREACTOMER-HSA-450531
AUF1 (hnRNP D0) binds and destabilizes mRNAREACTOMER-HSA-450408

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
243361682014Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models.141
118504022002PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays.83
182307612008Proximity of the poly(A)-binding protein to a premature termination codon inhibits mammalian nonsense-mediated mRNA decay.71
177854422007Human TOB, an antiproliferative transcription factor, is a poly(A)-binding protein-dependent positive regulator of cytoplasmic mRNA deadenylation.69
193694212009Uncoupling stress granule assembly and translation initiation inhibition.69
218830932012Critical roles of RNA helicase DDX3 and its interactions with eIF4E/PABP1 in stress granule assembly and stress response.67
220222682011A viral nuclear noncoding RNA binds re-localized poly(A) binding protein and is required for late KSHV gene expression.60
200984212010Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation.49
230412822012Interdomain allostery promotes assembly of the poly(A) mRNA complex with PABP and eIF4G.48
119975122002Paip1 interacts with poly(A) binding protein through two independent binding motifs.44

Citation

Dessen P

PABPC1 (poly(A) binding protein cytoplasmic 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43613/pabpc1