PAGE4 (PAGE family member 4)

2005-02-01  

Identity

HGNC
PAGE4
LOCATION
Xp11.23
LOCUSID
9506
ALIAS
CT16.7,GAGE-9,GAGEC1,JM-27,JM27,PAGE-1,PAGE-4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9506
MIM: 300287
HGNC: 4108
Ensembl: ENSG00000101951

Variants:

dbSNP: 9506
ClinVar: 9506
TCGA: ENSG00000101951
COSMIC: PAGE4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101951ENST00000218068O60829
ENSG00000101951ENST00000376141O60829

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
213574252011The cancer/testis antigen prostate-associated gene 4 (PAGE4) is a highly intrinsically disordered protein.35
262429132015Phosphorylation-induced Conformational Ensemble Switching in an Intrinsically Disordered Cancer/Testis Antigen.26
242631712014The Stress-response protein prostate-associated gene 4, interacts with c-Jun and potentiates its transactivation.19
245591712014Cancer/testis antigen PAGE4, a regulator of c-Jun transactivation, is phosphorylated by homeodomain-interacting protein kinase 1, a component of the stress-response pathway.18
124898492002PAGE4 is a cytoplasmic protein that is expressed in normal prostate and in prostate cancers.12
228851052012PAGE4 positivity is associated with attenuated AR signaling and predicts patient survival in hormone-naive prostate cancer.11
153627912004The expression of GAGE gene can predict aggressive biologic behavior of intestinal type of stomach cancer.10
306586792019PAGE4 promotes prostate cancer cells survive under oxidative stress through modulating MAPK/JNK/ERK pathway.0

Citation

Dessen P

PAGE4 (PAGE family member 4)

Atlas Genet Cytogenet Oncol Haematol. 2005-02-01

Online version: http://atlasgeneticsoncology.org/gene/43007/page4