PAIP1 (poly(A) binding protein interacting protein 1)

2019-04-01  

Identity

HGNC
PAIP1
LOCATION
5p12
LOCUSID
10605
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10605
MIM: 605184
HGNC: 16945
Ensembl: ENSG00000172239

Variants:

dbSNP: 10605
ClinVar: 10605
TCGA: ENSG00000172239
COSMIC: PAIP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172239ENST00000306846Q9H074
ENSG00000172239ENST00000338972Q9H074
ENSG00000172239ENST00000436644Q9H074
ENSG00000172239ENST00000504075A0A1D5RMS4
ENSG00000172239ENST00000504639D6R9H8
ENSG00000172239ENST00000508537D6RJ02
ENSG00000172239ENST00000511321D6RJF2
ENSG00000172239ENST00000514514D6REB4
ENSG00000172239ENST00000514816H0YA44
ENSG00000172239ENST00000515338D6RD97

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
Gene ExpressionREACTOMER-HSA-74160
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
Deadenylation of mRNAREACTOMER-HSA-429947

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
187254002008Poly(A)-binding protein-interacting protein 1 binds to eukaryotic translation initiation factor 3 to stimulate translation.46
119975122002Paip1 interacts with poly(A) binding protein through two independent binding motifs.44
243960662014Control of Paip1-eukayrotic translation initiation factor 3 interaction by amino acids through S6 kinase.12
293586942018Maternal whole blood cell miRNA-340 is elevated in gestational diabetes and inversely regulated by glucose and insulin.7
252666612014Paip1, an effective stimulator of translation initiation, is targeted by WWP2 for ubiquitination and degradation.4
292589052018Paip1 affects breast cancer cell growth and represents a novel prognostic biomarker.4
198510222009Crystallization and preliminary X-ray diffraction analysis of the middle domain of Paip1.1
215398102011Crystal structure of the middle domain of human poly(A)-binding protein-interacting protein 1.1
309923672019Polyadenylate-binding protein-interacting proteins PAIP1 and PAIP2 affect translation termination.1
307310742019Role of Paip1 on angiogenesis and invasion in pancreatic cancer.0

Citation

Dessen P

PAIP1 (poly(A) binding protein interacting protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2019-04-01

Online version: http://atlasgeneticsoncology.org/gene/57837/paip1