PAIP2 (poly(A) binding protein interacting protein 2)

2014-11-01  

Identity

HGNC
PAIP2
LOCATION
5q31.2
LOCUSID
51247
ALIAS
PAIP-2,PAIP2A
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51247
MIM: 605604
HGNC: 17970
Ensembl: ENSG00000120727

Variants:

dbSNP: 51247
ClinVar: 51247
TCGA: ENSG00000120727
COSMIC: PAIP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120727ENST00000265192Q9BPZ3
ENSG00000120727ENST00000394795Q9BPZ3
ENSG00000120727ENST00000507755D6RA77
ENSG00000120727ENST00000510080Q9BPZ3
ENSG00000120727ENST00000511706D6R9Y1

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
166016762006Poly(A) binding protein (PABP) homeostasis is mediated by the stability of its inhibitor, Paip2.48
151753422004Poly(A)-binding protein-interacting protein 2, a strong regulator of vascular endothelial growth factor mRNA.25
192407912009Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis.24
128208982003Fructose modulates GLUT5 mRNA stability in differentiated Caco-2 cells: role of cAMP-signalling pathway and PABP (polyadenylated-binding protein)-interacting protein (Paip) 2.15
239640952013A new role for the cellular PABP repressor Paip2 as an innate restriction factor capable of limiting productive cytomegalovirus replication.8
309923672019Polyadenylate-binding protein-interacting proteins PAIP1 and PAIP2 affect translation termination.1

Citation

Dessen P

PAIP2 (poly(A) binding protein interacting protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71636/paip2