PAK6 (p21 (RAC1) activated kinase 6)

2003-08-01  

Identity

HGNC
PAK6
LOCATION
15q15.1
LOCUSID
56924
ALIAS
PAK5

Other Information

Locus ID:

NCBI: 56924
MIM: 608110
HGNC: 16061
Ensembl: ENSG00000137843

Variants:

dbSNP: 56924
ClinVar: 56924
TCGA: ENSG00000137843
COSMIC: PAK6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137843ENST00000260404Q9NQU5
ENSG00000137843ENST00000260404A0A024R9Q4
ENSG00000137843ENST00000441369Q9NQU5
ENSG00000137843ENST00000441369A0A024R9Q4
ENSG00000137843ENST00000453867Q9NQU5
ENSG00000137843ENST00000453867A0A024R9Q4
ENSG00000137843ENST00000453867A0A0U1RQB7
ENSG00000137843ENST00000455577Q9NQU5
ENSG00000137843ENST00000542403Q9NQU5
ENSG00000137843ENST00000542403A0A024R9Q4
ENSG00000137843ENST00000558055H0YLZ9
ENSG00000137843ENST00000558106H0YMS4
ENSG00000137843ENST00000558183H0YK38
ENSG00000137843ENST00000558658Q9NQU5
ENSG00000137843ENST00000558658A0A024R9Q4
ENSG00000137843ENST00000558658H3BSN5
ENSG00000137843ENST00000558878H0YKB6
ENSG00000137843ENST00000559139H0YK74
ENSG00000137843ENST00000559617H0YK91
ENSG00000137843ENST00000560346Q9NQU5
ENSG00000137843ENST00000560346A0A024R9Q4
ENSG00000137843ENST00000560669H0YL16
ENSG00000137843ENST00000560684H0YL47
ENSG00000137843ENST00000560806H0YL02
ENSG00000137843ENST00000561230H0YM99

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
ErbB signaling pathwayKEGGko04012
Axon guidanceKEGGko04360
Focal adhesionKEGGko04510
T cell receptor signaling pathwayKEGGko04660
Regulation of actin cytoskeletonKEGGko04810
Renal cell carcinomaKEGGko05211
ErbB signaling pathwayKEGGhsa04012
Axon guidanceKEGGhsa04360
Focal adhesionKEGGhsa04510
T cell receptor signaling pathwayKEGGhsa04660
Regulation of actin cytoskeletonKEGGhsa04810
Renal cell carcinomaKEGGhsa05211
Ras signaling pathwayKEGGhsa04014
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Signaling by Robo receptorREACTOMER-HSA-376176
Activation of RacREACTOMER-HSA-428540

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
186423282008Increased PAK6 expression in prostate cancer and identification of PAK6 associated proteins.37
186766802008Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.32
196921682010Genetic susceptibility to distinct bladder cancer subphenotypes.25
184657532008p21 activated kinase 5 activates Raf-1 and targets it to mitochondria.23
204530002010A Large-scale genetic association study of esophageal adenocarcinoma risk.23
155503932005Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase.21
231328662013p21-Activated kinase 6 (PAK6) inhibits prostate cancer growth via phosphorylation of androgen receptor and tumorigenic E3 ligase murine double minute-2 (Mdm2).20
245767772014Expression and prognostic significance of p21-activated kinase 6 in hepatocellular carcinoma.17
263754022015Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain.16
236859562014P21-activated kinase 5 plays essential roles in the proliferation and tumorigenicity of human hepatocellular carcinoma.14

Citation

Dessen P

PAK6 (p21 (RAC1) activated kinase 6)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41635/pak6