PAM (peptidylglycine alpha-amidating monooxygenase)

2003-02-01  

Identity

HGNC
PAM
LOCATION
5q21.1
LOCUSID
5066
ALIAS
PAL,PHM
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5066
MIM: 170270
HGNC: 8596
Ensembl: ENSG00000145730

Variants:

dbSNP: 5066
ClinVar: 5066
TCGA: ENSG00000145730
COSMIC: PAM

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145730ENST00000304400P19021
ENSG00000145730ENST00000345721F8W8D9
ENSG00000145730ENST00000346918P19021
ENSG00000145730ENST00000348126P19021
ENSG00000145730ENST00000379799H7BYD9
ENSG00000145730ENST00000438793P19021
ENSG00000145730ENST00000455264P19021
ENSG00000145730ENST00000504691H0Y9I4
ENSG00000145730ENST00000505654D6RF09
ENSG00000145730ENST00000506006D6R961
ENSG00000145730ENST00000509832D6RCD5
ENSG00000145730ENST00000511477D6RAQ2
ENSG00000145730ENST00000511839D6RG20
ENSG00000145730ENST00000512073D6RDU2

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
244641002014Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes.111
203517142011Poor replication of candidate genes for major depressive disorder using genome-wide association data.92
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
268795432016Neuronal differentiation is associated with a redox-regulated increase of copper flow to the secretory pathway.22
220806262011A copper-methionine interaction controls the pH-dependent activation of peptidylglycine monooxygenase.15
161076992005Mammalian peptidylglycine alpha-amidating monooxygenase mRNA expression can be modulated by the La autoantigen.9
300545982018Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells.9
262968842015Striking Oxygen Sensitivity of the Peptidylglycine α-Amidating Monooxygenase (PAM) in Neuroendocrine Cells.8
299972552018PAM forms an atypical SCF ubiquitin ligase complex that ubiquitinates and degrades NMNAT2.7
283770492017The endocytic pathways of a secretory granule membrane protein in HEK293 cells: PAM and EGF traverse a dynamic multivesicular body network together.6

Citation

Dessen P

PAM (peptidylglycine alpha-amidating monooxygenase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41636/pam