PAQR3 (progestin and adipoQ receptor family member 3)

2008-08-01  

Identity

HGNC
LOCATION
4q21.21
LOCUSID
ALIAS
RKTG
FUSION GENES

Other Information

Locus ID:

NCBI: 152559
MIM: 614577
HGNC: 30130
Ensembl: ENSG00000163291

Variants:

dbSNP: 152559
ClinVar: 152559
TCGA: ENSG00000163291
COSMIC: PAQR3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163291ENST00000342820F8W784
ENSG00000163291ENST00000395594Q6TCH7
ENSG00000163291ENST00000508599D6RDU4
ENSG00000163291ENST00000511594Q6TCH7
ENSG00000163291ENST00000512733Q6TCH7
ENSG00000163291ENST00000512760Q6TCH7
ENSG00000163291ENST00000515853Q6TCH7

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491
RAF/MAP kinase cascadeREACTOMER-HSA-5673001
Negative regulation of MAPK pathwayREACTOMER-HSA-5675221
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
FCERI mediated MAPK activationREACTOMER-HSA-2871796
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-2 signalingREACTOMER-HSA-451927
Interleukin receptor SHC signalingREACTOMER-HSA-912526
Interleukin-3, 5 and GM-CSF signalingREACTOMER-HSA-512988
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
GRB2 events in EGFR signalingREACTOMER-HSA-179812
SHC1 events in EGFR signalingREACTOMER-HSA-180336
Signaling by Insulin receptorREACTOMER-HSA-74752
Insulin receptor signalling cascadeREACTOMER-HSA-74751
IRS-mediated signallingREACTOMER-HSA-112399
SOS-mediated signallingREACTOMER-HSA-112412
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
Signalling to ERKsREACTOMER-HSA-187687
Signalling to RASREACTOMER-HSA-167044
Signalling to p38 via RIT and RINREACTOMER-HSA-187706
Prolonged ERK activation eventsREACTOMER-HSA-169893
Frs2-mediated activationREACTOMER-HSA-170968
ARMS-mediated activationREACTOMER-HSA-170984
Signaling by PDGFREACTOMER-HSA-186797
Downstream signal transductionREACTOMER-HSA-186763
Signaling by VEGFREACTOMER-HSA-194138
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
VEGFR2 mediated cell proliferationREACTOMER-HSA-5218921
Signaling by SCF-KITREACTOMER-HSA-1433557
MAPK family signaling cascadesREACTOMER-HSA-5683057
MAPK1/MAPK3 signalingREACTOMER-HSA-5684996
Signaling by GPCRREACTOMER-HSA-372790
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)REACTOMER-HSA-2404192
IGF1R signaling cascadeREACTOMER-HSA-2428924
IRS-related events triggered by IGF1RREACTOMER-HSA-2428928
Signaling by LeptinREACTOMER-HSA-2586552
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
NCAM signaling for neurite out-growthREACTOMER-HSA-375165
RET signalingREACTOMER-HSA-8853659

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
177243432007Spatial regulation of Raf kinase signaling by RKTG.41
185152812008RKTG sequesters B-Raf to the Golgi apparatus and inhibits the proliferation and tumorigenicity of human malignant melanoma cells.25
247994622014A Golgi-specific protein PAQR3 is closely associated with the progression, metastasis and prognosis of human gastric cancers.20
185471652008Characterization of the topology and functional domains of RKTG.18
228281362012PAQR3 plays a suppressive role in the tumorigenesis of colorectal cancers.18
253301562014MicroRNA-137 upregulation increases bladder cancer cell proliferation and invasion by targeting PAQR3.18
195191722009Adiponectin identified as an agonist for PAQR3/RKTG using a yeast-based assay system.17
263114972015PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus.16
198843492010Regulation of G-protein signaling by RKTG via sequestration of the G betagamma subunit to the Golgi apparatus.15
285604312017Overexpression of miR-15b-5p promotes gastric cancer metastasis by regulating PAQR3.11

Citation

Dessen P

PAQR3 (progestin and adipoQ receptor family member 3)

Atlas Genet Cytogenet Oncol Haematol. 2008-08-01

Online version: http://atlasgeneticsoncology.org/gene/50305/paqr3