PARP2 (poly(ADP-ribose) polymerase 2)

2005-11-01  

Identity

HGNC
LOCATION
14q11.2
LOCUSID
ALIAS
ADPRT2,ADPRTL2,ADPRTL3,ARTD2,PARP-2,pADPRT-2
FUSION GENES

Other Information

Locus ID:

NCBI: 10038
MIM: 607725
HGNC: 272
Ensembl: ENSG00000129484

Variants:

dbSNP: 10038
ClinVar: 10038
TCGA: ENSG00000129484
COSMIC: PARP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000129484ENST00000250416Q9UGN5
ENSG00000129484ENST00000429687Q9UGN5
ENSG00000129484ENST00000527915G3V167
ENSG00000129484ENST00000529465E9PJ27
ENSG00000129484ENST00000539930H0YH02

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Base excision repairKEGGko03410
ApoptosisKEGGko04210
Base excision repairKEGGhsa03410
ApoptosisKEGGhsa04210
BER complexKEGGhsa_M00296
BER complexKEGGM00296
DNA RepairREACTOMER-HSA-73894
Base Excision RepairREACTOMER-HSA-73884
Resolution of Abasic Sites (AP sites)REACTOMER-HSA-73933
Resolution of AP sites via the multiple-nucleotide patch replacement pathwayREACTOMER-HSA-110373
POLB-Dependent Long Patch Base Excision RepairREACTOMER-HSA-110362
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through MMEJ (alt-NHEJ)REACTOMER-HSA-5685939
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
DNA Damage Recognition in GG-NERREACTOMER-HSA-5696394
Formation of Incision Complex in GG-NERREACTOMER-HSA-5696395
Dual Incision in GG-NERREACTOMER-HSA-5696400

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA166163418rucaparibChemicalLabelAnnotationassociated

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
279654142017Overlapping roles for PARP1 and PARP2 in the recruitment of endogenous XRCC1 and PNKP into oxidized chromatin.32
146991482004Poly(ADP-ribose) reactivates stalled DNA topoisomerase I and Induces DNA strand break resealing.31
200923592010Crystal structure of the catalytic domain of human PARP2 in complex with PARP inhibitor ABT-888.25
215772102011Poly(ADP-ribose)-dependent regulation of Snail1 protein stability.25
294674152018PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation.24
266737202016Single molecule detection of PARP1 and PARP2 interaction with DNA strand breaks and their poly(ADP-ribosyl)ation using high-resolution AFM imaging.21
270875682016New directions in poly(ADP-ribose) polymerase biology.21
258004402015Quantitative site-specific ADP-ribosylation profiling of DNA-dependent PARPs.20
267049742016PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage.18

Citation

Dessen P

PARP2 (poly(ADP-ribose) polymerase 2)

Atlas Genet Cytogenet Oncol Haematol. 2005-11-01

Online version: http://atlasgeneticsoncology.org/gene/43063/parp2