PARP3 (poly(ADP-ribose) polymerase family member 3)

2003-06-01  

Identity

HGNC
LOCATION
3p21.2
LOCUSID
ALIAS
ADPRT3,ADPRTL2,ADPRTL3,ARTD3,IRT1,PADPRT-3

Other Information

Locus ID:

NCBI: 10039
MIM: 607726
HGNC: 273
Ensembl: ENSG00000041880

Variants:

dbSNP: 10039
ClinVar: 10039
TCGA: ENSG00000041880
COSMIC: PARP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000041880ENST00000398755Q9Y6F1
ENSG00000041880ENST00000417220Q9Y6F1
ENSG00000041880ENST00000417220A0A024R2X5
ENSG00000041880ENST00000431474Q9Y6F1
ENSG00000041880ENST00000431474A0A024R2X5
ENSG00000041880ENST00000471971F8WAY7
ENSG00000041880ENST00000498510C9J9C7

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Base excision repairKEGGko03410
ApoptosisKEGGko04210
Base excision repairKEGGhsa03410
ApoptosisKEGGhsa04210
BER complexKEGGhsa_M00296
BER complexKEGGM00296

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA166163418rucaparibChemicalLabelAnnotationassociated

References

Pubmed IDYearTitleCitations
212117212011PARP-3 and APLF function together to accelerate nonhomologous end-joining.115
212703342011Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression.89
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
200649382010PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA.54
172033052007Genetic variation in the base excision repair pathway and bladder cancer risk.43
169246742007PARP-3 associates with polycomb group bodies and with components of the DNA damage repair machinery.40
290541152017Reversible mono-ADP-ribosylation of DNA breaks.36
245982532014PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways.31
293611322018Characterization of DNA ADP-ribosyltransferase activities of PARP2 and PARP3: new insights into DNA ADP-ribosylation.27
196921682010Genetic susceptibility to distinct bladder cancer subphenotypes.25

Citation

Dessen P

PARP3 (poly(ADP-ribose) polymerase family member 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/588/parp3