PARP4 (poly(ADP-ribose) polymerase family member 4)

2003-12-01  

Identity

HGNC
PARP4
LOCATION
13q12.12
LOCUSID
143
ALIAS
ADPRTL1,ARTD4,PARP-4,PARPL,PH5P,VAULT3,VPARP,VWA5C,p193
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 143
MIM: 607519
HGNC: 271
Ensembl: ENSG00000102699

Variants:

dbSNP: 143
ClinVar: 143
TCGA: ENSG00000102699
COSMIC: PARP4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102699ENST00000381989Q9UKK3

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Base excision repairKEGGko03410
ApoptosisKEGGko04210
Base excision repairKEGGhsa03410
ApoptosisKEGGhsa04210
BER complexKEGGhsa_M00296
BER complexKEGGM00296
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Nicotinate metabolismREACTOMER-HSA-196807
Nicotinamide salvagingREACTOMER-HSA-197264

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
128290192003PARP-1, a determinant of cell survival in response to DNA damage.102
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
172033052007Genetic variation in the base excision repair pathway and bladder cancer risk.43
186766802008Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.32
196921682010Genetic susceptibility to distinct bladder cancer subphenotypes.25
195360922009Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array.13
196251762009PTEN identified as important risk factor of chronic obstructive pulmonary disease.12
266993842016Germline PARP4 mutations in patients with primary thyroid and breast cancers.7
191701962009Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.5
237398672013Expression profiles of vault components MVP, TEP1 and vPARP and their correlation to other multidrug resistance proteins in ovarian cancer.1

Citation

Dessen P

PARP4 (poly(ADP-ribose) polymerase family member 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/587/parp4