PATJ (PATJ crumbs cell polarity complex component)

2016-05-01 Affiliation

Identity

HGNC

PATJ

LOCATION

1p31.3

LOCUSID

10207

ALIAS

Cipp,INADL,InaD-like,hINADL

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10207
MIM: 603199
HGNC: 28881
Ensembl: ENSG00000132849

Variants:

dbSNP: 10207
ClinVar: 10207
TCGA: ENSG00000132849
COSMIC: PATJ

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000132849	ENST00000307297	B4DE90
ENSG00000132849	ENST00000316485	A0A0X1KG69
ENSG00000132849	ENST00000371158	Q8NI35
ENSG00000132849	ENST00000465798	A0A0U1RQR3
ENSG00000132849	ENST00000484937	Q8NI35
ENSG00000132849	ENST00000490547	A0A0U1RRD7
ENSG00000132849	ENST00000494842	A0A0U1RQW4
ENSG00000132849	ENST00000613764	A0A087WUZ6
ENSG00000132849	ENST00000635023	A0A0U1RR46
ENSG00000132849	ENST00000635137	A0A0U1RQT2
ENSG00000132849	ENST00000642238	A0A2R8Y549
ENSG00000132849	ENST00000646453	A0A2R8Y5I3

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Tight junction	KEGG	ko04530
Tight junction	KEGG	hsa04530
Hippo signaling pathway	KEGG	hsa04390
Hippo signaling pathway	KEGG	ko04390
Cell-Cell communication	REACTOME	R-HSA-1500931
Cell junction organization	REACTOME	R-HSA-446728
Cell-cell junction organization	REACTOME	R-HSA-421270
Tight junction interactions	REACTOME	R-HSA-420029

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
18824598	2009	The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells.	57
11964389	2002	hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells.	46
16129888	2005	PATJ connects and stabilizes apical and lateral components of tight junctions in human intestinal cells.	42
17235357	2007	PATJ regulates directional migration of mammalian epithelial cells.	37
17287269	2007	PATJ, a tight junction-associated PDZ protein, is a novel degradation target of high-risk human papillomavirus E6 and the alternatively spliced isoform 18 E6.	31
19255144	2009	Similar and distinct properties of MUPP1 and Patj, two homologous PDZ domain-containing tight-junction proteins.	28
26933062	2016	Cytokinesis involves a nontranscriptional function of the Hippo pathway effector YAP.	17
19563532	2009	Pals-associated tight junction protein functionally links dopamine and angiotensin II to the regulation of sodium transport in renal epithelial cells.	10
30582445	2019	PATJ Low Frequency Variants Are Associated With Worse Ischemic Stroke Functional Outcome.	4

Citation

Dessen P

PATJ (PATJ crumbs cell polarity complex component)

Atlas Genet Cytogenet Oncol Haematol. 2016-05-01

Online version: http://atlasgeneticsoncology.org/gene/78310/patj