PATL1 (PAT1 homolog 1, processing body mRNA decay factor)

2014-11-01  

Identity

HGNC
PATL1
LOCATION
11q12.1
LOCUSID
219988
ALIAS
Pat1b,hPat1b
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 219988
MIM: 614660
HGNC: 26721
Ensembl: ENSG00000166889

Variants:

dbSNP: 219988
ClinVar: 219988
TCGA: ENSG00000166889
COSMIC: PATL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166889ENST00000300146Q86TB9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Decapping complexKEGGhsa_M00395
Decapping complexKEGGM00395
Gene ExpressionREACTOMER-HSA-74160
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
mRNA decay by 5' to 3' exoribonucleaseREACTOMER-HSA-430039

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
205849872010Human Pat1b connects deadenylation with mRNA decapping and controls the assembly of processing bodies.61
179369232007Identification of PatL1, a human homolog to yeast P body component Pat1.30
205438182010The C-terminal alpha-alpha superhelix of Pat is required for mRNA decapping in metazoa.28
208266992010Distinct functions of maternal and somatic Pat1 protein paralogs.27
208522612011The human Pat1b protein: a novel mRNA deadenylation factor identified by a new immunoprecipitation technique.21
220903462012RNA-related nuclear functions of human Pat1b, the P-body mRNA decay factor.15
235351752013Role of Rck-Pat1b binding in assembly of processing-bodies.9
224379412012Identification of the P-body component PATL1 as a novel ALG-2-interacting protein by in silico and far-Western screening of proline-rich proteins.7
287682022017Dual RNA Processing Roles of Pat1b via Cytoplasmic Lsm1-7 and Nuclear Lsm2-8 Complexes.7
313400472019A low-complexity region in human XRN1 directly recruits deadenylation and decapping factors in 5'-3' messenger RNA decay.2

Citation

Dessen P

PATL1 (PAT1 homolog 1, processing body mRNA decay factor)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71678/patl1