PAXX (PAXX non-homologous end joining factor)

2017-08-01  

Identity

HGNC
PAXX
LOCATION
9q34.3
LOCUSID
286257
ALIAS
C9orf142,XLS

Other Information

Locus ID:

NCBI: 286257
MIM: 616315
HGNC: 27849
Ensembl: ENSG00000148362

Variants:

dbSNP: 286257
ClinVar: 286257
TCGA: ENSG00000148362
COSMIC: PAXX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148362ENST00000371620Q9BUH6

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
277058002016PAXX Is an Accessory c-NHEJ Factor that Associates with Ku70 and Has Overlapping Functions with XLF.26
305797082019Synthetic lethality between DNA repair factors Xlf and Paxx is rescued by inactivation of Trp53.4
302500672018PAXX and its paralogs synergistically direct DNA polymerase λ activity in DNA repair.1
255740252015DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair.0
256705042015Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway.0
302384272018PAXX Participates in Base Excision Repair via Interacting with Pol β and Contributes to TMZ Resistance in Glioma Cells.0

Citation

Dessen P

PAXX (PAXX non-homologous end joining factor)

Atlas Genet Cytogenet Oncol Haematol. 2017-08-01

Online version: http://atlasgeneticsoncology.org/gene/57040/paxx