Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PBX2 (PBX homeobox 2)

Identity

Alias (NCBI)G17
HOX12
PBX2MHC
HGNC (Hugo) PBX2
HGNC Alias symbG17
HOX12
PBX2MHC
HGNC Previous namepre-B-cell leukemia transcription factor 2
 pre-B-cell leukemia homeobox 2
LocusID (NCBI) 5089
Atlas_Id 41647
Location 6p21.32  [Link to chromosome band 6p21]
Location_base_pair Starts at 32184733 and ends at 32190202 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PBX2 (6p21.32) / DERA (12p12.3)PBX2 (6p21.32) / TUBB4A (19p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PBX2   8633
Cards
Entrez_Gene (NCBI)PBX2  5089  PBX homeobox 2
AliasesG17; HOX12; PBX2MHC
GeneCards (Weizmann)PBX2
Ensembl hg19 (Hinxton)ENSG00000204304 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000204304 [Gene_View]  ENSG00000204304 [Sequence]  chr6:32184733-32190202 [Contig_View]  PBX2 [Vega]
ICGC DataPortalENSG00000204304
TCGA cBioPortalPBX2
AceView (NCBI)PBX2
Genatlas (Paris)PBX2
WikiGenes5089
SOURCE (Princeton)PBX2
Genetics Home Reference (NIH)PBX2
Genomic and cartography
GoldenPath hg38 (UCSC)PBX2  -     chr6:32184733-32190202 -  6p21.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PBX2  -     6p21.32   [Description]    (hg19-Feb_2009)
GoldenPathPBX2 - 6p21.32 [CytoView hg19]  PBX2 - 6p21.32 [CytoView hg38]
ImmunoBaseENSG00000204304
genome Data Viewer NCBIPBX2 [Mapview hg19]  
OMIM176311   
Gene and transcription
Genbank (Entrez)BC003111 BC082261 BQ182713 BT009823 DB162975
RefSeq transcript (Entrez)NM_002586
RefSeq genomic (Entrez)NC_000006 NT_113891 NT_167244 NT_167246 NT_167247 NT_167248 NT_167249
Consensus coding sequences : CCDS (NCBI)PBX2
Alternative Splicing GalleryENSG00000204304
Gene ExpressionPBX2 [ NCBI-GEO ]   PBX2 [ EBI - ARRAY_EXPRESS ]   PBX2 [ SEEK ]   PBX2 [ MEM ]
Gene Expression Viewer (FireBrowse)PBX2 [ Firebrowse - Broad ]
GenevisibleExpression of PBX2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5089
GTEX Portal (Tissue expression)PBX2
Human Protein AtlasENSG00000204304-PBX2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP40425   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP40425  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP40425
Splice isoforms : SwissVarP40425
PhosPhoSitePlusP40425
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like_sf    Homeobox_CS    Homeobox_dom    PBX   
Domain families : Pfam (Sanger)Homeodomain (PF00046)    PBC (PF03792)   
Domain families : Pfam (NCBI)pfam00046    pfam03792   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)PBX2
DMDM Disease mutations5089
Blocks (Seattle)PBX2
SuperfamilyP40425
Human Protein Atlas [tissue]ENSG00000204304-PBX2 [tissue]
Peptide AtlasP40425
HPRD08890
IPIIPI00028416   IPI01021527   IPI01022892   IPI01022588   
Protein Interaction databases
DIP (DOE-UCLA)P40425
IntAct (EBI)P40425
FunCoupENSG00000204304
BioGRIDPBX2
STRING (EMBL)PBX2
ZODIACPBX2
Ontologies - Pathways
QuickGOP40425
Ontology : AmiGOnuclear chromatin  RNA polymerase II regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  eye development  chromatin binding  protein binding  nucleus  transcription factor complex  brain development  transcription factor binding  animal organ morphogenesis  proximal/distal pattern formation  embryonic limb morphogenesis  positive regulation of transcription by RNA polymerase II  embryonic organ development  neuron development  
Ontology : EGO-EBInuclear chromatin  RNA polymerase II regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  eye development  chromatin binding  protein binding  nucleus  transcription factor complex  brain development  transcription factor binding  animal organ morphogenesis  proximal/distal pattern formation  embryonic limb morphogenesis  positive regulation of transcription by RNA polymerase II  embryonic organ development  neuron development  
NDEx NetworkPBX2
Atlas of Cancer Signalling NetworkPBX2
Wikipedia pathwaysPBX2
Orthology - Evolution
OrthoDB5089
GeneTree (enSembl)ENSG00000204304
Phylogenetic Trees/Animal Genes : TreeFamPBX2
HOGENOMP40425
Homologs : HomoloGenePBX2
Homology/Alignments : Family Browser (UCSC)PBX2
Gene fusions - Rearrangements
Fusion : QuiverPBX2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPBX2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PBX2
dbVarPBX2
ClinVarPBX2
1000_GenomesPBX2 
Exome Variant ServerPBX2
GNOMAD BrowserENSG00000204304
Varsome BrowserPBX2
Genetic variants : HAPMAP5089
Genomic Variants (DGV)PBX2 [DGVbeta]
DECIPHERPBX2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPBX2 
Mutations
ICGC Data PortalPBX2 
TCGA Data PortalPBX2 
Broad Tumor PortalPBX2
OASIS PortalPBX2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPBX2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPBX2
Mutations and Diseases : HGMDPBX2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PBX2
DgiDB (Drug Gene Interaction Database)PBX2
DoCM (Curated mutations)PBX2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PBX2 (select a term)
intoGenPBX2
Cancer3DPBX2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176311   
Orphanet
DisGeNETPBX2
MedgenPBX2
Genetic Testing Registry PBX2
NextProtP40425 [Medical]
TSGene5089
GENETestsPBX2
Target ValidationPBX2
Huge Navigator PBX2 [HugePedia]
snp3D : Map Gene to Disease5089
BioCentury BCIQPBX2
ClinGenPBX2
Clinical trials, drugs, therapy
Protein Interactions : CTD5089
Pharm GKB GenePA32971
Clinical trialPBX2
Miscellaneous
canSAR (ICR)PBX2 (select the gene name)
HarmonizomePBX2
DataMed IndexPBX2
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePBX2
EVEXPBX2
GoPubMedPBX2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jul 16 15:28:50 CEST 2020

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