Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PBX4 (PBX homeobox 4)

Identity

Alias_namespre-B-cell leukemia transcription factor 4
pre-B-cell leukemia homeobox 4
Other alias-
HGNC (Hugo) PBX4
LocusID (NCBI) 80714
Atlas_Id 41649
Location 19p13.11  [Link to chromosome band 19p13]
Location_base_pair Starts at 19561707 and ends at 19618916 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MGA (15q15.1) / PBX4 (19p13.11)PBX4 (19p13.11) / SH3RF3 (2q12.3)SLC44A2 (19p13.2) / PBX4 (19p13.11)
MGA 15q15.1 / PBX4 19p13.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(15;19)(q15;p13) MGA/PBX4
SLC44A2/PBX4 (19p13)

External links

Nomenclature
HGNC (Hugo)PBX4   13403
Cards
Entrez_Gene (NCBI)PBX4  80714  PBX homeobox 4
Aliases
GeneCards (Weizmann)PBX4
Ensembl hg19 (Hinxton)ENSG00000105717 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105717 [Gene_View]  ENSG00000105717 [Sequence]  chr19:19561707-19618916 [Contig_View]  PBX4 [Vega]
ICGC DataPortalENSG00000105717
TCGA cBioPortalPBX4
AceView (NCBI)PBX4
Genatlas (Paris)PBX4
WikiGenes80714
SOURCE (Princeton)PBX4
Genetics Home Reference (NIH)PBX4
Genomic and cartography
GoldenPath hg38 (UCSC)PBX4  -     chr19:19561707-19618916 -  19p13.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PBX4  -     19p13.11   [Description]    (hg19-Feb_2009)
GoldenPathPBX4 - 19p13.11 [CytoView hg19]  PBX4 - 19p13.11 [CytoView hg38]
ImmunoBaseENSG00000105717
Mapping of homologs : NCBIPBX4 [Mapview hg19]  PBX4 [Mapview hg38]
OMIM608127   
Gene and transcription
Genbank (Entrez)AJ300182 AK097427 AK301631 BC033067 BC141859
RefSeq transcript (Entrez)NM_025245
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PBX4
Cluster EST : UnigeneHs.466257 [ NCBI ]
CGAP (NCI)Hs.466257
Alternative Splicing GalleryENSG00000105717
Gene ExpressionPBX4 [ NCBI-GEO ]   PBX4 [ EBI - ARRAY_EXPRESS ]   PBX4 [ SEEK ]   PBX4 [ MEM ]
Gene Expression Viewer (FireBrowse)PBX4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)80714
GTEX Portal (Tissue expression)PBX4
Human Protein AtlasENSG00000105717-PBX4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BYU1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BYU1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BYU1
Splice isoforms : SwissVarQ9BYU1
PhosPhoSitePlusQ9BYU1
Domaine pattern : Prosite (Expaxy)HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like_sf    Homeobox_dom    PBX   
Domain families : Pfam (Sanger)Homeobox (PF00046)    PBC (PF03792)   
Domain families : Pfam (NCBI)pfam00046    pfam03792   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)PBX4
DMDM Disease mutations80714
Blocks (Seattle)PBX4
SuperfamilyQ9BYU1
Human Protein Atlas [tissue]ENSG00000105717-PBX4 [tissue]
Peptide AtlasQ9BYU1
HPRD16287
IPIIPI00019294   
Protein Interaction databases
DIP (DOE-UCLA)Q9BYU1
IntAct (EBI)Q9BYU1
FunCoupENSG00000105717
BioGRIDPBX4
STRING (EMBL)PBX4
ZODIACPBX4
Ontologies - Pathways
QuickGOQ9BYU1
Ontology : AmiGODNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  XY body  protein binding  nucleus  regulation of transcription by RNA polymerase II  transcription by RNA polymerase II  sequence-specific DNA binding  positive regulation of transcription, DNA-templated  
Ontology : EGO-EBIDNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  XY body  protein binding  nucleus  regulation of transcription by RNA polymerase II  transcription by RNA polymerase II  sequence-specific DNA binding  positive regulation of transcription, DNA-templated  
NDEx NetworkPBX4
Atlas of Cancer Signalling NetworkPBX4
Wikipedia pathwaysPBX4
Orthology - Evolution
OrthoDB80714
GeneTree (enSembl)ENSG00000105717
Phylogenetic Trees/Animal Genes : TreeFamPBX4
HOGENOMQ9BYU1
Homologs : HomoloGenePBX4
Homology/Alignments : Family Browser (UCSC)PBX4
Gene fusions - Rearrangements
Fusion : MitelmanMGA/PBX4 [15q15.1/19p13.11]  [t(15;19)(q15;p13)]  
Fusion : MitelmanSLC44A2/PBX4 [19p13.2/19p13.11]  [t(19;19)(p13;p13)]  
Fusion PortalMGA 15q15.1 PBX4 19p13.11 LUAD
Fusion : QuiverPBX4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPBX4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PBX4
dbVarPBX4
ClinVarPBX4
1000_GenomesPBX4 
Exome Variant ServerPBX4
ExAC (Exome Aggregation Consortium)ENSG00000105717
GNOMAD BrowserENSG00000105717
Varsome BrowserPBX4
Genetic variants : HAPMAP80714
Genomic Variants (DGV)PBX4 [DGVbeta]
DECIPHERPBX4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPBX4 
Mutations
ICGC Data PortalPBX4 
TCGA Data PortalPBX4 
Broad Tumor PortalPBX4
OASIS PortalPBX4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPBX4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPBX4
Mutations and Diseases : HGMDPBX4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PBX4
DgiDB (Drug Gene Interaction Database)PBX4
DoCM (Curated mutations)PBX4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PBX4 (select a term)
intoGenPBX4
Cancer3DPBX4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608127   
Orphanet
DisGeNETPBX4
MedgenPBX4
Genetic Testing Registry PBX4
NextProtQ9BYU1 [Medical]
TSGene80714
GENETestsPBX4
Target ValidationPBX4
Huge Navigator PBX4 [HugePedia]
snp3D : Map Gene to Disease80714
BioCentury BCIQPBX4
ClinGenPBX4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD80714
Chemical/Pharm GKB GenePA32973
Clinical trialPBX4
Miscellaneous
canSAR (ICR)PBX4 (select the gene name)
DataMed IndexPBX4
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePBX4
EVEXPBX4
GoPubMedPBX4
iHOPPBX4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Wed Nov 13 17:59:53 CET 2019
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