PBXIP1 (PBX homeobox interacting protein 1)

2003-12-01  

Identity

HGNC
PBXIP1
LOCATION
1q21.3
LOCUSID
57326
ALIAS
HPIP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57326
MIM: 618819
HGNC: 21199
Ensembl: ENSG00000163346

Variants:

dbSNP: 57326
ClinVar: 57326
TCGA: ENSG00000163346
COSMIC: PBXIP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163346ENST00000368460Q5T173
ENSG00000163346ENST00000368463Q96AQ6
ENSG00000163346ENST00000368465Q96AQ6
ENSG00000163346ENST00000490230F2Z2Z8

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
221874272012Functional regulation of pre-B-cell leukemia homeobox interacting protein 1 (PBXIP1/HPIP) in erythroid differentiation.12
244705472014Pre-B-cell leukemia homeobox interacting protein 1 is overexpressed in astrocytoma and promotes tumor cell growth and migration.9
240389482013HPIP is upregulated in liver cancer and promotes hepatoma cell proliferation via activation of G2/M transition.7
250603512015Potential role of hematopoietic pre-B-cell leukemia transcription factor-interacting protein in oral carcinogenesis.7
265906062016The involvement of hematopoietic pre-B cell leukemia transcription factor-interacting protein in regulating epithelial-mesenchymal transition of human spinal glioblastoma.4
271788202016HPIP Silencing Prevents Epithelial-Mesenchymal Transition Induced by TGF-β1 in Human Ovarian Cancer Cells.4
277489442016HPIP promotes gastric cancer cell proliferation through activation of cap-dependent translation.3
264973662015Identification of hallmarks of lung adenocarcinoma prognosis using whole genome sequencing.1
321319342020[Effect of Hematopoietic Pre-B-cell Leukemia Transcription Factor Interacting Protein Knockdown on Proliferation,Cell Cycle and Apoptosis in Pancreatic Cancer Cells].0

Citation

Dessen P

PBXIP1 (PBX homeobox interacting protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/41650/pbxip1