PCBP1 (poly(rC) binding protein 1)

2007-02-01  

Identity

HGNC
LOCATION
2p13.3
LOCUSID
ALIAS
HEL-S-85,HNRPE1,HNRPX,hnRNP-E1,hnRNP-X
FUSION GENES

Other Information

Locus ID:

NCBI: 5093
MIM: 601209
HGNC: 8647
Ensembl: ENSG00000169564

Variants:

dbSNP: 5093
ClinVar: 5093
TCGA: ENSG00000169564
COSMIC: PCBP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169564ENST00000303577Q15365
ENSG00000169564ENST00000303577Q53SS8

Expression (GTEx)

0
100
200
300
400
500
600
700

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
FerroptosisKEGGko04216
FerroptosisKEGGhsa04216

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
371579502023PCBP1 protects bladder cancer cells from mitochondria injury and ferroptosis by inducing LACTB mRNA degradation.3
375589232023Classification of IDH wild-type glioblastoma tumorspheres into low- and high-invasion groups based on their transcriptional program.1
379272132023PCBP1 regulates LIFR through FAM3C to maintain breast cancer stem cell self-renewal and invasiveness.1
371579502023PCBP1 protects bladder cancer cells from mitochondria injury and ferroptosis by inducing LACTB mRNA degradation.3
375589232023Classification of IDH wild-type glioblastoma tumorspheres into low- and high-invasion groups based on their transcriptional program.1
379272132023PCBP1 regulates LIFR through FAM3C to maintain breast cancer stem cell self-renewal and invasiveness.1
347303952022Host Restriction Factor A3G Inhibits the Replication of Enterovirus D68 by Competitively Binding the 5' Untranslated Region with PCBP1.5
352158842022Poly(rC)-Binding Protein 1 Limits Hepatitis C Virus Virion Assembly and Secretion.3
352875462022PolyC-RNA-binding protein 1 (PCBP1) enhances tropomyosin 3 (TPM3) mRNA stability to promote the progression of esophageal squamous cell carcinoma.1
352909032022Poly(rC)-binding protein 1 represses ferritinophagy-mediated ferroptosis in head and neck cancer.22
355498702022Poly(rC) Binding Protein 1 Represses the Translation of STAT3 through 5' UTR.5
355898112022PCBP1 is associated with rheumatoid arthritis by affecting RNA products of genes involved in immune response in Th1 cells.3
358968972022Overexpression of splicing factor poly(rC)-binding protein 1 elicits cycle arrest, apoptosis induction, and p73 splicing in human cervical carcinoma cells.3
347303952022Host Restriction Factor A3G Inhibits the Replication of Enterovirus D68 by Competitively Binding the 5' Untranslated Region with PCBP1.5
352158842022Poly(rC)-Binding Protein 1 Limits Hepatitis C Virus Virion Assembly and Secretion.3

Citation

Dessen P

PCBP1 (poly(rC) binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43728/pcbp1