PCBP2 (poly(rC) binding protein 2)

2007-02-01  

Identity

HGNC
PCBP2
LOCATION
12q13.13
LOCUSID
5094
ALIAS
HNRNPE2,HNRPE2,hnRNP-E2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5094
MIM: 601210
HGNC: 8648
Ensembl: ENSG00000197111

Variants:

dbSNP: 5094
ClinVar: 5094
TCGA: ENSG00000197111
COSMIC: PCBP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197111ENST00000359282Q15366
ENSG00000197111ENST00000359462Q15366
ENSG00000197111ENST00000359462A0A384N6B9
ENSG00000197111ENST00000437231Q15366
ENSG00000197111ENST00000439930Q15366
ENSG00000197111ENST00000447282Q15366
ENSG00000197111ENST00000455667Q15366
ENSG00000197111ENST00000546463Q15366
ENSG00000197111ENST00000546652F8W1G6
ENSG00000197111ENST00000547859H3BSS4
ENSG00000197111ENST00000548933Q15366
ENSG00000197111ENST00000549863F8VZX2
ENSG00000197111ENST00000550192F8VTZ0
ENSG00000197111ENST00000550520F8VXH9
ENSG00000197111ENST00000550585H3BND9
ENSG00000197111ENST00000551104F8W0G4
ENSG00000197111ENST00000552296Q15366
ENSG00000197111ENST00000552819Q15366
ENSG00000197111ENST00000552980H3BSP4
ENSG00000197111ENST00000553064F8VRH0
ENSG00000197111ENST00000562264H3BRU6

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
Negative regulators of RIG-I/MDA5 signalingREACTOMER-HSA-936440
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
FerroptosisKEGGko04216
FerroptosisKEGGhsa04216

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
202111352010miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts.202
198815092009PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4.122
175819942007Cellular protein modification by poliovirus: the two faces of poly(rC)-binding protein.74
124149432002Distinct poly(rC) binding protein KH domain determinants for poliovirus translation initiation and viral RNA replication.73
120110882002Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA.49
236408982013Each member of the poly-r(C)-binding protein 1 (PCBP) family exhibits iron chaperone activity toward ferritin.45
216327512011Poly(C)-binding protein 2 interacts with sequences required for viral replication in the hepatitis C virus (HCV) 5' untranslated region and directs HCV RNA replication through circularizing the viral genome.44
181743142008Identification of PCBP2, a facilitator of IRES-mediated translation, as a novel constituent of stress granules and processing bodies.38
248431202014Iron chaperones PCBP1 and PCBP2 mediate the metallation of the dinuclear iron enzyme deoxyhypusine hydroxylase.36
192115662009Depletion of the poly(C)-binding proteins alphaCP1 and alphaCP2 from K562 cells leads to p53-independent induction of cyclin-dependent kinase inhibitor (CDKN1A) and G1 arrest.34

Citation

Dessen P

PCBP2 (poly(rC) binding protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46265/pcbp2