PCDH10 (protocadherin 10)

2007-02-01  

Identity

HGNC
PCDH10
LOCATION
4q28.3
LOCUSID
57575
ALIAS
OL-PCDH,PCDH19
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57575
MIM: 608286
HGNC: 13404
Ensembl: ENSG00000138650

Variants:

dbSNP: 57575
ClinVar: 57575
TCGA: ENSG00000138650
COSMIC: PCDH10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138650ENST00000264360Q9P2E7
ENSG00000138650ENST00000264360X5D999
ENSG00000138650ENST00000618019Q9P2E7

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
162474582006Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation.86
190845282009Methylation of protocadherin 10, a novel tumor suppressor, is associated with poor prognosis in patients with gastric cancer.64
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
250852462014A novel wnt regulatory axis in endometrioid endometrial cancer.47
186448942008Contact-dependent promotion of cell migration by the OL-protocadherin-Nap1 interaction.45
268714742016MALAT1 long ncRNA promotes gastric cancer metastasis by suppressing PCDH10.38
231800192013Frequent epigenetic silencing of PCDH10 by methylation in human colorectal cancer.21
196811202009Protocadherin PCDH10, involved in tumor progression, is a frequent and early target of promoter hypermethylation in cervical cancer.19
222068712012Role of PCDH10 and its hypermethylation in human gastric cancer.17
238394932013Epigenetic alteration: new insights moving from tissue to plasma - the example of PCDH10 promoter methylation in colorectal cancer.17

Citation

Dessen P

PCDH10 (protocadherin 10)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46192/pcdh10