PCDH17 (protocadherin 17)

2010-07-01  

Identity

HGNC
PCDH17
LOCATION
13q21.1
LOCUSID
27253
ALIAS
PCDH68,PCH68
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 27253
MIM: 611760
HGNC: 14267
Ensembl: ENSG00000118946

Variants:

dbSNP: 27253
ClinVar: 27253
TCGA: ENSG00000118946
COSMIC: PCDH17

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000118946ENST00000377918O14917
ENSG00000118946ENST00000484979O14917
ENSG00000118946ENST00000612954A0A087WXV2
ENSG00000118946ENST00000615375A0A087X099

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
212133692011High resolution ArrayCGH and expression profiling identifies PTPRD and PCDH17/PCH68 as tumor suppressor gene candidates in laryngeal squamous cell carcinoma.31
229267512013Protocadherin 17 acts as a tumour suppressor inducing tumour cell apoptosis and autophagy, and is frequently methylated in gastric and colorectal cancers.28
202000742010Frequent silencing of protocadherin 17, a candidate tumour suppressor for esophageal squamous cell carcinoma.27
236847852013Protocadherin 17 regulates presynaptic assembly in topographic corticobasal Ganglia circuits.25
280701202018The protocadherin 17 gene affects cognition, personality, amygdala structure and function, synapse development and risk of major mood disorders.20
267006202016An epigenetic biomarker combination of PCDH17 and POU4F2 detects bladder cancer accurately by methylation analyses of urine sediment DNA in Han Chinese.18
273511302016Protocadherin 17 functions as a tumor suppressor suppressing Wnt/β-catenin signaling and cell metastasis and is frequently methylated in breast cancer.18
176729182007Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.17
222075562012PCDH17 gene promoter demethylation and cell cycle arrest by genistein in gastric cancer.12
243664982014Protocadherin-17 promoter methylation in serum-derived DNA is associated with poor prognosis of bladder cancer.10

Citation

Dessen P

PCDH17 (protocadherin 17)

Atlas Genet Cytogenet Oncol Haematol. 2010-07-01

Online version: http://atlasgeneticsoncology.org/gene/51560/pcdh17