PCF11 (PCF11 cleavage and polyadenylation factor subunit)

2014-11-01  

Identity

HGNC
LOCATION
11q14.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 51585
MIM: 608876
HGNC: 30097
Ensembl: ENSG00000165494

Variants:

dbSNP: 51585
ClinVar: 51585
TCGA: ENSG00000165494
COSMIC: PCF11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165494ENST00000298281O94913
ENSG00000165494ENST00000530304E9PKN0
ENSG00000165494ENST00000530660E9PQ01
ENSG00000165494ENST00000530906E9PNY7
ENSG00000165494ENST00000533018E9PQF9

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Transcription TerminationREACTOMER-HSA-73856
Cleavage of Growing Transcript in the Termination RegionREACTOMER-HSA-109688
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
mRNA 3'-end processingREACTOMER-HSA-72187
Processing of Capped Intronless Pre-mRNAREACTOMER-HSA-75067
Processing of Intronless Pre-mRNAsREACTOMER-HSA-77595

References

Pubmed IDYearTitleCitations
110600402000Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors.84
180867052008Human Pcf11 enhances degradation of RNA polymerase II-associated nascent RNA and transcriptional termination.31
176066392007Transcription termination factor Pcf11 limits the processivity of Pol II on an HIV provirus to repress gene expression.20
308408962019Regulation of Intronic Polyadenylation by PCF11 Impacts mRNA Expression of Long Genes.10
305523332018Transcriptome 3'end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastoma.8
308196442019Selective Roles of Vertebrate PCF11 in Premature and Full-Length Transcript Termination.8
291965352017WNK1 kinase and the termination factor PCF11 connect nuclear mRNA export with transcription.6
301397992018Reconstitution of mammalian cleavage factor II involved in 3' processing of mRNA precursors.4

Citation

Dessen P

PCF11 (PCF11 cleavage and polyadenylation factor subunit)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71759/pcf11