PCK2 (phosphoenolpyruvate carboxykinase 2, mitochondrial)

2015-02-01  

Identity

HGNC
PCK2
LOCATION
14q11.2
LOCUSID
5106
ALIAS
PEPCK,PEPCK-M,PEPCK2

Other Information

Locus ID:

NCBI: 5106
MIM: 614095
HGNC: 8725
Ensembl: ENSG00000100889

Variants:

dbSNP: 5106
ClinVar: 5106
TCGA: ENSG00000100889
COSMIC: PCK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100889ENST00000216780Q16822
ENSG00000100889ENST00000216780A0A384MTT2
ENSG00000100889ENST00000396973Q16822
ENSG00000100889ENST00000545054Q16822
ENSG00000100889ENST00000558096H0YML5
ENSG00000100889ENST00000559171H0YMY3
ENSG00000100889ENST00000559250H0YM31
ENSG00000100889ENST00000559503H0YMA5
ENSG00000100889ENST00000559584H0YKC4
ENSG00000100889ENST00000559837H0YMU6
ENSG00000100889ENST00000560106H0YNH9
ENSG00000100889ENST00000560736H0YNG4
ENSG00000100889ENST00000561286Q16822

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycolysis / GluconeogenesisKEGGko00010
Citrate cycle (TCA cycle)KEGGko00020
Pyruvate metabolismKEGGko00620
PPAR signaling pathwayKEGGko03320
Insulin signaling pathwayKEGGko04910
Adipocytokine signaling pathwayKEGGko04920
Glycolysis / GluconeogenesisKEGGhsa00010
Citrate cycle (TCA cycle)KEGGhsa00020
Pyruvate metabolismKEGGhsa00620
PPAR signaling pathwayKEGGhsa03320
Insulin signaling pathwayKEGGhsa04910
Adipocytokine signaling pathwayKEGGhsa04920
Metabolic pathwaysKEGGhsa01100
Proximal tubule bicarbonate reclamationKEGGko04964
Proximal tubule bicarbonate reclamationKEGGhsa04964
Gluconeogenesis, oxaloacetate => fructose-6PKEGGhsa_M00003
Gluconeogenesis, oxaloacetate => fructose-6PKEGGM00003
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
FoxO signaling pathwayKEGGhsa04068
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glucose metabolismREACTOMER-HSA-70326
GluconeogenesisREACTOMER-HSA-70263
Insulin resistanceKEGGhsa04931

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
206826872010Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program.88
195872432009Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes.68
264740642015Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth.60
246326152015PCK2 activation mediates an adaptive response to glucose depletion in lung cancer.55
264816632015PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth.52
249732132014Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) is a pro-survival, endoplasmic reticulum (ER) stress response gene involved in tumor cell adaptation to nutrient availability.47
186604892008Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.26
195215122009Endurance capacity, not body size, determines physical activity levels: role of skeletal muscle PEPCK.26
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
207974232011C/EBPβ is AMP kinase sensitive and up-regulates PEPCK in response to ER stress in hepatoma cells.16

Citation

Dessen P

PCK2 (phosphoenolpyruvate carboxykinase 2, mitochondrial)

Atlas Genet Cytogenet Oncol Haematol. 2015-02-01

Online version: http://atlasgeneticsoncology.org/gene/54985/pck2