PDC (phosducin)

2014-11-01  

Identity

HGNC
PDC
LOCATION
1q31.1
LOCUSID
5132
ALIAS
MEKA,PHD,PhLOP,PhLP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5132
MIM: 171490
HGNC: 8759
Ensembl: ENSG00000116703

Variants:

dbSNP: 5132
ClinVar: 5132
TCGA: ENSG00000116703
COSMIC: PDC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116703ENST00000391997P20941
ENSG00000116703ENST00000497198P20941
ENSG00000116703ENST00000497198A0A024R982

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
retina
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
164210942006SUMO-1 controls the protein stability and the biological function of phosducin.30
199598752009Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice.12
147583352004Mutation screening of the phosducin gene PDC in patients with retinitis pigmentosa and allied diseases.2
147583352004Mutation screening of the phosducin gene PDC in patients with retinitis pigmentosa and allied diseases.2
208047852010Phosducin and monomeric β-actin have common epitope recognized by anti-phosducin antibodies.1
211912912011The identification of phosducin as a novel candidate gene for hypertension and its role in sympathetic activation.1
223655732013Phosducin rs12402521 polymorphism predicts development of hypertension in young subjects with overweight or obesity.1
251536852015Phosducin regulates secretory activity in TT line of thyroid parafollicular C cells.0

Citation

Dessen P

PDC (phosducin)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71781/pdc