PDCL (phosducin like)

2014-11-01  

Identity

HGNC
LOCATION
9q33.2
LOCUSID
ALIAS
PhLP
FUSION GENES

Other Information

Locus ID:

NCBI: 5082
MIM: 604421
HGNC: 8770
Ensembl: ENSG00000136940

Variants:

dbSNP: 5082
ClinVar: 5082
TCGA: ENSG00000136940
COSMIC: PDCL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136940ENST00000259467Q13371
ENSG00000136940ENST00000394285H0Y3M0
ENSG00000136940ENST00000436632H0Y5D3

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta foldingREACTOMER-HSA-6814122

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
167170952006Mechanism of assembly of G protein betagamma subunits by protein kinase CK2-phosphorylated phosducin-like protein and the cytosolic chaperonin complex.32
157458792005Phosducin-like protein regulates G-protein betagamma folding by interaction with tailless complex polypeptide-1alpha: dephosphorylation or splicing of PhLP turns the switch toward regulation of Gbetagamma folding.20
256755012015Structures of the Gβ-CCT and PhLP1-Gβ-CCT complexes reveal a mechanism for G-protein β-subunit folding and Gβγ dimer assembly.15
193767732009Role of molecular chaperones in G protein beta5/regulator of G protein signaling dimer assembly and G protein betagamma dimer specificity.11
124662822003Regulation of phosducin-like protein by casein kinase 2 and N-terminal splicing.7
194035262009Differential inhibitor of Gbetagamma signaling to AKT and ERK derived from phosducin-like protein: effect on sphingosine 1-phosphate-induced endothelial cell migration and in vitro angiogenesis.6
238880552013Splice isoforms of phosducin-like protein control the expression of heterotrimeric G proteins.4

Citation

Dessen P

PDCL (phosducin like)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71784/pdcl